嗜酸性粒细胞是否能预测鼻息肉的临床严重程度?

IF 2.3
Multidisciplinary Respiratory Medicine Pub Date : 2017-08-21 eCollection Date: 2017-01-01 DOI:10.1186/s40248-017-0102-7
Figen Aslan, Eren Altun, Serpil Paksoy, Gulay Turan
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引用次数: 23

摘要

背景:虽然鼻息肉是最常见的疾病之一,但其发病机制尚不清楚。由于嗜酸性粒细胞是鼻息肉组织中相当大比例的主要炎症细胞,因此它们被认为可能对疾病的发病和预后负责。本研究的目的是探讨鼻息肉的粘膜和外周嗜酸性粒细胞增多及其与疾病严重程度的关系。方法:对53例鼻息肉患者行鼻内窥镜手术。记录患者术前隆德-麦凯计算机断层扫描(CT)评分和隆德-肯尼迪内镜评分。鼻息肉组织采用苏木精和伊红染色,光镜下高倍镜(HPF, 400倍)对患者进行嗜酸性粒细胞计数,并将患者分为粘膜嗜酸性粒细胞计数高组和粘膜嗜酸性粒细胞计数低组。结果:粘膜嗜酸性粒细胞计数高的患者的平均Lund-MacKay CT评分和内镜下的平均Lund-Kennedy评分高于粘膜嗜酸性粒细胞计数低的患者。同样,外周嗜酸性粒细胞计数高的患者的平均Lund-MacKay CT评分和平均Lund-Kennedy内镜评分明显高于外周嗜酸性粒细胞计数低的患者(p p)。结论:粘膜和外周嗜酸性粒细胞计数可作为预测鼻息肉疾病严重程度的标志。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Could Eosinophilia predict clinical severity in nasal polyps?

Background: Although nasal polyps are one of the most frequent diseases, their etiopathogenesis remains unclear.Since eosinophils are the main inflammatory cells in the substantial proportion of nasal polyp tissues, they are considered potentially responsible for the etiopathogenesis and prognosis of the disease. Aim of this study was to investigate the relation between mucosal and peripheral eosinophilia and their relation with disease severity in nasal polyps.

Methods: The study included 53 patients with nasal polyps who underwent endoscopic sinus surgery. Preoperative Lund-MacKay computed tomography (CT) scores and the Lund-Kennedy endoscopic scores of the patients were recorded. Nasal polyp tissues were stained with hematoxylin and eosin, eosinophil counts were performed using high-power field (HPF, 400×) under the light microscope, and the patients were grouped as those with high mucosal eosinophil count and those with low mucosal eosinophil count.

Results: The mean Lund-MacKay CT score and the mean Lund-Kennedy endoscopic score were higher in the patients with high mucosal eosinophil count than in those with low mucosal eosinophil count. Likewise, the mean Lund-MacKay CT score and the mean Lund-Kennedy endoscopic scores were significantly higher in the patients with high peripheral eosinophil count than in those with low peripheral eosinophil count (p < 0.05 for both). Moreover, the mean peripheral eosinophil count was significantly higher in the patients with high mucosal eosinophil count than in those with low mucosal eosinophil count (p < 0.05).

Conclusion: Mucosal and peripheral eosinophilia can be used as a marker to predict disease severity in nasal polyps.

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来源期刊
Multidisciplinary Respiratory Medicine
Multidisciplinary Respiratory Medicine Medicine-Pulmonary and Respiratory Medicine
自引率
0.00%
发文量
23
期刊介绍: Multidisciplinary Respiratory Medicine is the official journal of the Italian Respiratory Society - Società Italiana di Pneumologia (IRS/SIP). The journal publishes on all aspects of respiratory medicine and related fields, with a particular focus on interdisciplinary and translational research. The interdisciplinary nature of the journal provides a unique opportunity for researchers, clinicians and healthcare professionals across specialties to collaborate and exchange information. The journal provides a high visibility platform for the publication and dissemination of top quality original scientific articles, reviews and important position papers documenting clinical and experimental advances.
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