丝素/聚氨酯共混贴片对大鼠血管的影响。

IF 1.6 4区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Organogenesis Pub Date : 2017-10-02 Epub Date: 2017-09-21 DOI:10.1080/15476278.2017.1344376
Kazumi Shimada, Akira Higuchi, Ryota Kubo, Tomoaki Murakami, Yasumoto Nakazawa, Ryou Tanaka
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引用次数: 18

摘要

膜片移植广泛应用于各种血管手术,如血管狭窄的检测修复或扩张。膨胀聚四氟乙烯(ePTFE)贴片柔韧性好,处理起来也很好,但由于它们不可生物吸收,因此会永久留在体内,因此存在钙化问题。开发一种可替代的生物相容性贴片是很重要的。丝素蛋白(SF)作为一种生物相容性材料被开发出来,但它缺乏作为手术贴片所需的弹性。聚氨酯(PU)也是一种众所周知的弹性体,因此本研究的重点是SF和PU共混材料,其重量比为5:5 (SF/PU)。为了评价SF/PU贴片的效果,将贴片植入大鼠腹主动脉,对照组采用ePTFE贴片。由于SF/PU贴片比ePTFE贴片更灵活,因此更容易植入。植入后1周,SF/PU补片已被细胞和胶原纤维浸润。ePTFE对照贴片直到3个月时才积累胶原纤维,4周时发生钙化。SF/PU贴片在3个月内未出现任何钙化迹象。本研究解决了与分离使用SF相关的问题,并表明SF/PU贴片可以被认为是ePTFE的有用替代品,以克服钙化问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The effect of a silk Fibroin/Polyurethane blend patch on rat Vessels.

The effect of a silk Fibroin/Polyurethane blend patch on rat Vessels.

The effect of a silk Fibroin/Polyurethane blend patch on rat Vessels.

Patch grafts are widely used in various kind of vascular surgeries such as detect repair or dilation of vascular stenosis. Expanded polytetrafluoroethylene (ePTFE) patches are flexible and handle well, but have shown problems with calcification as they are non-bioabsorbable and therefore permanently remain in the body. It is important to develop an alternative biocompatible patch. Silk fibroin (SF) was developed as a biocompatible material, but it lacks of the elasticity required for surgery as a patch. Polyurethane (PU) is also a well-known elastomer so this study focused on the SF and the PU blend materials with a weight ratio of 5:5 (SF/PU). To evaluate the SF/PU patch, the patches were implanted into the abdominal aortas of rats, using the ePTFE patch in the control group. Because it was more flexible the SF/PU patch was easier to implant than the ePTFE patch. At 1 week after implantation, the SF/PU patch had been infiltrated with cells and collagen fiber. The ePTFE control patch did not accumulate collagen fiber until 3 months and calcification occurred at 4 weeks. The SF/PU patch did not present any signs of calcification for 3 months. This study addressed the problems associated with using SF in isolation and showed that the SF/PU patch can be considered as a useful alternative to the ePTFE to overcome the problem of calcification.

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来源期刊
Organogenesis
Organogenesis BIOCHEMISTRY & MOLECULAR BIOLOGY-DEVELOPMENTAL BIOLOGY
CiteScore
4.10
自引率
4.30%
发文量
6
审稿时长
>12 weeks
期刊介绍: Organogenesis is a peer-reviewed journal, available in print and online, that publishes significant advances on all aspects of organ development. The journal covers organogenesis in all multi-cellular organisms and also includes research into tissue engineering, artificial organs and organ substitutes. The overriding criteria for publication in Organogenesis are originality, scientific merit and general interest. The audience of the journal consists primarily of researchers and advanced students of anatomy, developmental biology and tissue engineering. The emphasis of the journal is on experimental papers (full-length and brief communications), but it will also publish reviews, hypotheses and commentaries. The Editors encourage the submission of addenda, which are essentially auto-commentaries on significant research recently published elsewhere with additional insights, new interpretations or speculations on a relevant topic. If you have interesting data or an original hypothesis about organ development or artificial organs, please send a pre-submission inquiry to the Editor-in-Chief. You will normally receive a reply within days. All manuscripts will be subjected to peer review, and accepted manuscripts will be posted to the electronic site of the journal immediately and will appear in print at the earliest opportunity thereafter.
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