着丝粒染色质的翻译后修饰。

Q2 Medicine

Progress in molecular and subcellular biology Pub Date : 2017-01-01 DOI:10.1007/978-3-319-58592-5_9

Ana García Del Arco, Sylvia Erhardt

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引用次数: 2

摘要

染色质结构的调控对于基因表达等DNA过程的控制是重要的，染色质的错误调控与多种疾病有关。组蛋白的共价翻译后修饰是调控染色质结构的重要途径，不同的染色质区域具有组蛋白修饰的特定特征。着丝粒染色质的组成与其他染色质结构明显不同，主要由组蛋白h3变体CENP-A的存在决定。在这里，我们总结了着丝粒染色质的组成和我们所知道的关于翻译后修饰的差异调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Post-translational Modifications of Centromeric Chromatin.

Regulation of chromatin structures is important for the control of DNA processes such as gene expression, and misregulation of chromatin is implicated in diverse diseases. Covalent post-translational modifications of histones are a prominent way to regulate chromatin structure and different chromatin regions bear their specific signature of histone modifications. The composition of centromeric chromatin is significantly different from other chromatin structures and mainly defined by the presence of the histone H3-variant CENP-A. Here we summarize the composition of centromeric chromatin and what we know about its differential regulation by post-translational modifications.

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来源期刊

Progress in molecular and subcellular biology Medicine-Medicine (all)

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Molecular biology has been providing an overwhelming amount of data on the structural components and molecular machineries of the cell and its organelles and the complexity of intra- and intercellular communication. The molecular basis of hereditary and acquired diseases is beginning to be unravelled, and profound new insights into development and evolutionary biology have been gained from molecular approaches. Progress in Molecular and Subcellular Biology summarises the most recent developments in this fascinating area of biology.