细菌外膜囊泡:新的见解和应用。

Q3 Biochemistry, Genetics and Molecular Biology

Molecular Membrane Biology Pub Date : 2016-09-01 DOI:10.1080/09687688.2017.1400602

Deepak Anand, Arunima Chaudhuri

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引用次数: 38

摘要

外膜囊泡(omv)(直径约50-250 nm)是病原细菌和非病原细菌分泌的典型最终产物。本文主要对革兰氏阴性菌产生的omv进行综述。我们通过几个有代表性的例子，概述了OMV的结构、调节其产生的各种因素以及它们在调节宿主免疫反应中的作用。鉴于omv携带的各种货物的重要性，我们讨论了它们进入宿主细胞的不同模式以及这些omv高通量检测的进展。omv的一个显著应用是在疫苗接种领域;我们讨论了它在预防人类疾病(如百日咳、脑膜炎、志贺氏菌病和爱德华氏菌病等水产养殖危害疾病)方面的成功。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bacterial outer membrane vesicles: New insights and applications.

Outer membrane vesicles (OMVs) (∼50-250 nm in diameter) are produced by both pathogenic and nonpathogenic bacteria as a canonical end product of secretion. In this review, we focus on the OMVs produced by gram-negative bacteria. We provide an overview of the OMV structure, various factors regulating their production, and their role in modulating host immune response using a few representative examples. In light of the importance of the diverse cargoes carried by OMVs, we discuss the different modes of their entry into the host cell and advances in the high-throughput detection of these OMVs. A conspicuous application of OMVs lies in the field of vaccination; we discuss its success in immunization against human diseases such as pertussis, meningitis, shigellosis and aqua-farming endangering diseases like edwardsiellosis.

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来源期刊

Molecular Membrane Biology 生物-生化与分子生物学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Cessation. Molecular Membrane Biology provides a forum for high quality research that serves to advance knowledge in molecular aspects of biological membrane structure and function. The journal welcomes submissions of original research papers and reviews in the following areas: • Membrane receptors and signalling • Membrane transporters, pores and channels • Synthesis and structure of membrane proteins • Membrane translocation and targeting • Lipid organisation and asymmetry • Model membranes • Membrane trafficking • Cytoskeletal and extracellular membrane interactions • Cell adhesion and intercellular interactions • Molecular dynamics and molecular modelling of membranes. • Antimicrobial peptides.