Actinomadura Parvosata Subsp. Kistnae 的完整基因组序列，新型天然产品（生物）化学的丰富来源。

Journal of Genomics Pub Date : 2017-07-02 eCollection Date: 2017-01-01 DOI:10.7150/jgen.19673

Kalina Kusserow, Tobias A M Gulder

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引用次数: 0

摘要

基因组测序和生物信息学分析表明，土壤放线菌株 Actinomadura parvosata subsp.其中包括多酮、核糖体和非核糖体肽，以及大量编码未知天然产物的萜类生物合成基因位点。因此，该菌株的基因组数据是挖掘新型功能代谢物和新型生物催化剂的基因组宝库。

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Complete Genome Sequence of Actinomadura Parvosata Subsp. Kistnae, A Rich Source of Novel Natural Product (Bio-)Chemistry.

The soil dwelling actinomycete strain Actinomadura parvosata subsp. kistnae is the producer of the antiviral antibiotics kistamicin A and B. Genome sequencing and bioinformatic analysis revealed the presence of the kistamycin biosynthetic gene cluster responsible for the formation of these non-ribosomal peptides as well as an impressive number of yet uncharacterized biosynthetic pathways. This includes polyketide, ribosomal and non-ribosomal peptide and a large number of terpenoid biosynthetic loci encoding yet unknown natural products. The genomic data of this strain is thus a treasure trove for genome mining for novel functional metabolites and new biocatalysts.

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来源期刊

Journal of Genomics

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Journal of Genomics publishes papers of high quality in all areas of gene, genetics, genomics, proteomics, metabolomics, DNA/RNA, computational biology, bioinformatics, and other relevant areas of research and application. Articles published by the journal are rigorously peer-reviewed. Types of articles include: Research paper, Short research communication, Review or mini-reviews, Commentary, Database, Software.