褪黑素对周围神经损伤和神经系统发育的有益作用。

IF 1.1 Q4 CLINICAL NEUROLOGY

Journal of Brachial Plexus and Peripheral Nerve Injury Pub Date : 2017-02-16 eCollection Date: 2017-01-01 DOI:10.1055/s-0036-1597838

Yigit Uyanikgil, Turker Cavusoglu, Kubilay Dogan Kılıc, Gurkan Yigitturk, Servet Celik, Richard Shane Tubbs, Mehmet Turgut

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引用次数: 14

摘要

本文综述了褪黑素(melatonin, MLT)在神经系统发育中的新作用，以及内源性和外源性褪黑素在减轻组织和神经损伤程度方面的作用。MLT是一种有效的自由基清除剂和抗氧化剂。由于内源性MLT水平在衰老时显著下降，这些研究结果表明，这种抗氧化剂的丧失可能导致一些与年龄相关的神经退行性疾病的发病率或严重程度。考虑到MLT在克服周围神经和其他器官损伤方面的高疗效，应认真考虑为此目的进行临床试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System.

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Useful Effects of Melatonin in Peripheral Nerve Injury and Development of the Nervous System.

Abstract This review summarizes the role of melatonin (MLT) in defense against toxic-free radicals and its novel effects in the development of the nervous system, and the effect of endogenously produced and exogenously administered MLT in reducing the degree of tissue and nerve injuries. MLT was recently reported to be an effective free radical scavenger and antioxidant. Since endogenous MLT levels fall significantly in senility, these findings imply that the loss of this antioxidant could contribute to the incidence or severity of some age-related neurodegenerative diseases. Considering the high efficacy of MLT in overcoming much of the injury not only to the peripheral nerve but also to other organs, clinical trials for this purpose should be seriously considered.

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来源期刊

Journal of Brachial Plexus and Peripheral Nerve Injury CLINICAL NEUROLOGY-

CiteScore

1.70

自引率

14.30%

发文量

审稿时长

12 weeks

期刊介绍： JBPPNI is an open access, peer-reviewed online journal that will encompass all aspects of basic and clinical research findings, in the area of brachial plexus and peripheral nerve injury. Injury in this context refers to congenital, inflammatory, traumatic, degenerative and neoplastic processes, including neurofibromatosis. Papers on diagnostic and imaging aspects of the peripheral nervous system are welcomed as well. The peripheral nervous system is unique in its complexity and scope of influence. There are areas of interest in the anatomy, physiology, metabolism, phylogeny, and limb growth tropism of peripheral nerves.