{"title":"双孔通道与帕金森病：联系在哪里？","authors":"Pilar Rivero-Ríos, Belén Fernández, Jesús Madero-Pérez, María Romo Lozano, Sabine Hilfiker","doi":"10.1166/msr.2016.1051","DOIUrl":null,"url":null,"abstract":"<p><p>Two-pore channels are endolysosomal Ca<sup>2+</sup> release channels involved in proper trafficking to and from those organelles. They are the likely targets for the Ca<sup>2+</sup>-mobilizing messenger NAADP, and are further regulated by a variety of mechanisms including phosphoinositide levels and Rab proteins. As discussed here, recent studies highlight a role for these channels in the pathomechanism(s) underlying Parkinson's disease, with important implications for possible alternative treatment strategies.</p>","PeriodicalId":74176,"journal":{"name":"Messenger (Los Angeles, Calif. : Print)","volume":"5 1-2","pages":"67-75"},"PeriodicalIF":0.0000,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436604/pdf/emss-72808.pdf","citationCount":"0","resultStr":"{\"title\":\"Two-Pore Channels and Parkinson's Disease: Where's the Link?\",\"authors\":\"Pilar Rivero-Ríos, Belén Fernández, Jesús Madero-Pérez, María Romo Lozano, Sabine Hilfiker\",\"doi\":\"10.1166/msr.2016.1051\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Two-pore channels are endolysosomal Ca<sup>2+</sup> release channels involved in proper trafficking to and from those organelles. They are the likely targets for the Ca<sup>2+</sup>-mobilizing messenger NAADP, and are further regulated by a variety of mechanisms including phosphoinositide levels and Rab proteins. As discussed here, recent studies highlight a role for these channels in the pathomechanism(s) underlying Parkinson's disease, with important implications for possible alternative treatment strategies.</p>\",\"PeriodicalId\":74176,\"journal\":{\"name\":\"Messenger (Los Angeles, Calif. : Print)\",\"volume\":\"5 1-2\",\"pages\":\"67-75\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436604/pdf/emss-72808.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Messenger (Los Angeles, Calif. : Print)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1166/msr.2016.1051\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Messenger (Los Angeles, Calif. : Print)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1166/msr.2016.1051","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Two-Pore Channels and Parkinson's Disease: Where's the Link?
Two-pore channels are endolysosomal Ca2+ release channels involved in proper trafficking to and from those organelles. They are the likely targets for the Ca2+-mobilizing messenger NAADP, and are further regulated by a variety of mechanisms including phosphoinositide levels and Rab proteins. As discussed here, recent studies highlight a role for these channels in the pathomechanism(s) underlying Parkinson's disease, with important implications for possible alternative treatment strategies.
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