组蛋白乙酰转移酶 MOF 的结构和功能。

IF 1.1 Q4 BIOPHYSICS
AIMS Biophysics Pub Date : 2015-01-01 Epub Date: 2015-10-19 DOI:10.3934/biophy.2015.4.555
Qiao Yi Chen, Max Costa, Hong Sun
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引用次数: 0

摘要

MOF 最早是在黑腹果蝇中被发现的,它是剂量补偿复合体的一个重要组成部分。作为组蛋白乙酰转移酶 MYST 家族的成员,MOF 能将乙酰基特异性地沉积到组蛋白 H4 第 16 个赖氨酸上。在整个进化过程中,MOF 及其哺乳动物同源物保持了高度保守的底物特异性和相似的酶活性。MOF 在剂量补偿、ESC 自我更新、DNA 损伤和修复、细胞存活以及基因表达调控等方面发挥着重要作用。MOF 的失调与多种人类癌症的形成和发展有关。本综述将讨论哺乳动物 hMOF 的结构和活性及其在 H4K16 乙酰化、DNA 损伤反应、干细胞多能性和癌变中的功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Structure and function of histone acetyltransferase MOF.

Structure and function of histone acetyltransferase MOF.

Structure and function of histone acetyltransferase MOF.

MOF was first identified in Drosophila melanogaster as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and similar enzymatic activities. MOF plays important roles in dosage compensation, ESC self-renewal, DNA damage and repair, cell survival, and gene expression regulation. Dysregulation of MOF has been implicated in tumor formation and progression of many types of human cancers. This review will discuss the structure and activity of mammalian hMOF as well as its function in H4K16 acetylation, DNA damage response, stem cell pluripotency, and carcinogenesis.

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来源期刊
AIMS Biophysics
AIMS Biophysics BIOPHYSICS-
CiteScore
2.40
自引率
20.00%
发文量
16
审稿时长
8 weeks
期刊介绍: AIMS Biophysics is an international Open Access journal devoted to publishing peer-reviewed, high quality, original papers in the field of biophysics. We publish the following article types: original research articles, reviews, editorials, letters, and conference reports. AIMS Biophysics welcomes, but not limited to, the papers from the following topics: · Structural biology · Biophysical technology · Bioenergetics · Membrane biophysics · Cellular Biophysics · Electrophysiology · Neuro-Biophysics · Biomechanics · Systems biology
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