Nihal Başak, Yakup Aksoy, Ayhan Kaydu, Ömer Fatih Şahin
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引用次数: 5
摘要
目的:探讨氯诺昔康对异丙酚注射相关疼痛的预防作用。材料和方法:本研究经我院伦理委员会批准。使用计算机随机化软件，120名接受择期手术的患者被分配到四个相等的组。第一组(对照组)在麻醉诱导前立即静脉给予0.9% NaCl等渗溶液(安慰剂)10 ml (IV)。第二、三、四组同一注射剂分别含氯诺昔康2 mg、4 mg、8 mg。然后将止血带应用于前臂两分钟。疼痛评估采用言语疼痛评分。结果:I组与II组、I组与III组、I组与IV组、II组与III组疼痛严重程度评分差异均有统计学意义(p结论:氯诺昔康组与对照组相比，丙泊酚注射组疼痛严重程度均显著降低。剂量为4毫克时效果最大。
Lornoxicam use to reduce the pain associated with propofol injection.
Aim: To investigate the efficacy of lornoxicam in the prevention of the pain associated with propofol injection.
Material and method: Approval for this study was granted by the ethics committee of our hospital. Using a computer randomisation software, 120 patients undergoing elective surgery were assigned to four equal groups. In Group I (control group), immediately before anaesthesia induction, 10 ml of isotonic 0.9% NaCl solution (placebo) was administered intravenously (IV). In Groups II, III and IV, the same injection contained 2 mg, 4 mg and 8 mg of lornoxicam respectively. A tourniquet was then applied to the forearm for two minutes. Pain evaluation was made using a verbal pain score.
Results: Differences in pain severity scores were statistically significant between Groups I and II, Groups I and III, Groups I and IV and between Groups II and III (p < 0.05). However, no significant difference was determined between Groups III and IV (p = 0.401).
Conclusion: In all groups administered with lornoxicam, there was a significant reduction in the severity of pain associated with propofol injection, in comparison with the control group. Maximum effect is obtained with a dose of 4 mg.
期刊介绍：
Libyan Journal of Medicine (LJM) is a peer-reviewed, Open Access, international medical journal aiming to promote heath and health education by publishing high-quality medical research in the different disciplines of medicine.
LJM was founded in 2006 by a group of enthusiastic Libyan medical scientists who looked at the contribution of Libyan publications to the international medical literature and saw that a publication outlet was missing. To fill this gap they launched LJM as a tool for transferring current medical knowledge to and from colleagues in developing countries, particularly African countries, as well as internationally.The journal is still led by a group of Libyan physicians inside and outside Libya, but it also enjoys support and recognition from the international medical community.
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