Tolterodine酒石酸。

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2017-01-01 Epub Date: 2017-03-30 DOI:10.1016/bs.podrm.2017.02.007

Gennady Ananchenko, Jasmina Novakovic

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引用次数: 1

摘要

酒石酸托特罗定属于毒蕈碱受体拮抗剂家族，用于治疗膀胱过度活跃综合征。本章概述了物理、分析和ADME配置文件;重点介绍化学合成方法;并讨论了托特罗定作为游离碱和/或其l-酒石酸盐在溶液和固体中的稳定性。本章提供的信息是基于同行评议文献、药典报告(USP、EP)和作者数据。专利文献只包括在少数情况下。

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Tolterodine Tartrate.

Tolterodine tartrate belongs to the family of muscarinic receptor antagonists and is indicated for the treatment of overactive urinary bladder syndrome. This chapter provides an overview of physical, analytical, and ADME profiles; highlights methods of chemical synthesis; and discusses stability of tolterodine as a free base and/or its l-tartrate salt in solution and in the solid state. The information presented in this chapter is based on the peer-reviewed literature, compendial reports (USP, EP), and authors' data. Patent literature is included only in a few instances.

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

发文量