{"title":"Lomefloxacin。","authors":"Reem I Al-Wabli","doi":"10.1016/bs.podrm.2017.02.004","DOIUrl":null,"url":null,"abstract":"<p><p>Lomefloxacin is a second-generation difluorinated broad-spectrum quinolone antibiotic. It is used for the treatment of bronchitis, urinary tract infection, conjunctivitis, otitis externa, and otitis media. A comprehensive profile was performed on lomefloxacin including nomenclature, formulae, elemental composition appearance, and physical characteristics. Spectral methods including ultraviolet spectrum, vibrational spectrum, <sup>1</sup>H and <sup>13</sup>C nuclear magnetic resonance one- and two-dimensional spectra, and mass spectrum were used for both identification and analysis of the drug. The profile also contains the reported methods of analysis such as voltammetric, polarographic, spectrophotometric, fluorimetric, chromatographic, capillary electrophoresis, and immunoassay methods. In addition, the uses, pharmacokinetics, and chemical synthesis of lomefloxacin are described.</p>","PeriodicalId":20802,"journal":{"name":"Profiles of drug substances, excipients, and related methodology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.podrm.2017.02.004","citationCount":"2","resultStr":"{\"title\":\"Lomefloxacin.\",\"authors\":\"Reem I Al-Wabli\",\"doi\":\"10.1016/bs.podrm.2017.02.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Lomefloxacin is a second-generation difluorinated broad-spectrum quinolone antibiotic. It is used for the treatment of bronchitis, urinary tract infection, conjunctivitis, otitis externa, and otitis media. A comprehensive profile was performed on lomefloxacin including nomenclature, formulae, elemental composition appearance, and physical characteristics. Spectral methods including ultraviolet spectrum, vibrational spectrum, <sup>1</sup>H and <sup>13</sup>C nuclear magnetic resonance one- and two-dimensional spectra, and mass spectrum were used for both identification and analysis of the drug. The profile also contains the reported methods of analysis such as voltammetric, polarographic, spectrophotometric, fluorimetric, chromatographic, capillary electrophoresis, and immunoassay methods. In addition, the uses, pharmacokinetics, and chemical synthesis of lomefloxacin are described.</p>\",\"PeriodicalId\":20802,\"journal\":{\"name\":\"Profiles of drug substances, excipients, and related methodology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/bs.podrm.2017.02.004\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Profiles of drug substances, excipients, and related methodology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/bs.podrm.2017.02.004\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2017/3/31 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"Pharmacology, Toxicology and Pharmaceutics\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Profiles of drug substances, excipients, and related methodology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/bs.podrm.2017.02.004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2017/3/31 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"Pharmacology, Toxicology and Pharmaceutics","Score":null,"Total":0}
Lomefloxacin is a second-generation difluorinated broad-spectrum quinolone antibiotic. It is used for the treatment of bronchitis, urinary tract infection, conjunctivitis, otitis externa, and otitis media. A comprehensive profile was performed on lomefloxacin including nomenclature, formulae, elemental composition appearance, and physical characteristics. Spectral methods including ultraviolet spectrum, vibrational spectrum, 1H and 13C nuclear magnetic resonance one- and two-dimensional spectra, and mass spectrum were used for both identification and analysis of the drug. The profile also contains the reported methods of analysis such as voltammetric, polarographic, spectrophotometric, fluorimetric, chromatographic, capillary electrophoresis, and immunoassay methods. In addition, the uses, pharmacokinetics, and chemical synthesis of lomefloxacin are described.
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