格列齐特。

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2017-01-01 Epub Date: 2017-04-12 DOI:10.1016/bs.podrm.2017.02.003

Fatmah A M Al-Omary

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引用次数: 7

摘要

格列齐特是第二代口服降糖药，用于治疗非胰岛素依赖型糖尿病。它属于磺酰脲类，通过抑制atp依赖性钾通道刺激胰腺β-细胞分泌胰岛素。格列齐特还具有独特的抗氧化性能和其他有益的血液生物学作用。该概况代表了对标题药物的物理性质、化学合成、光谱表征(FTIR、1H NMR、13C NMR、UV和单晶x射线)、分析方法、药理作用以及药代动力学和药效学性质的全面描述。

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Gliclazide.

Gliclazide is a second-generation oral hypoglycemic drug used for the treatment of noninsulin-dependent diabetes mellitus. It belongs to the sulfonylurea class that stimulates insulin secretion from pancreatic β-cells by inhibiting ATP-dependent potassium channels. Gliclazide also possesses unique antioxidant properties and other beneficial hemobiological effects. This profile represents a comprehensive description of the physical properties, chemical synthesis, spectroscopic characterization (FTIR, ¹H NMR, ¹³C NMR, UV, and single-crystal X-ray), methods of analysis, pharmacological actions, and pharmacokinetic and pharmacodynamic properties of the title drug.

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

发文量