与寨卡病毒相关的小头畸形的潜在机制。

Q1 Biochemistry, Genetics and Molecular Biology

Wiley Interdisciplinary Reviews: Developmental Biology Pub Date : 2017-07-01 Epub Date: 2017-04-06 DOI:10.1002/wdev.273

Emily Merfeld, Lily Ben-Avi, Mason Kennon, Kara L Cerveny

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引用次数: 0

摘要

最近在巴西爆发的寨卡病毒（ZIKV）与受感染母亲所生婴儿的小头畸形有关。随着疫情的蔓延，快速的科学调查正在揭示产前感染 ZIKV 如何导致小头畸形。在这篇分析中，我们概述了小头畸形和ZIKV，探讨了产前ZIKV感染与小头畸形之间的联系，并重点介绍了最近关于产前ZIKV感染如何耗尽发育中大脑的神经祖细胞池的见解。WIREs Dev Biol 2017, 6:e273. doi: 10.1002/wdev.273 与本文相关的更多资源，请访问 WIREs 网站。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Potential mechanisms of Zika-linked microcephaly.

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Potential mechanisms of Zika-linked microcephaly.

A recent outbreak of Zika virus (ZIKV) in Brazil is associated with microcephaly in infants born of infected mothers. As this pandemic spreads, rapid scientific investigation is shedding new light on how prenatal infection with ZIKV causes microcephaly. In this analysis we provide an overview of both microcephaly and ZIKV, explore the connection between prenatal ZIKV infection and microcephaly, and highlight recent insights into how prenatal ZIKV infection depletes the pool of neural progenitors in the developing brain. WIREs Dev Biol 2017, 6:e273. doi: 10.1002/wdev.273 For further resources related to this article, please visit the WIREs website.

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来源期刊

Wiley Interdisciplinary Reviews: Developmental Biology DEVELOPMENTAL BIOLOGY-

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期刊介绍： Developmental biology is concerned with the fundamental question of how a single cell, the fertilized egg, ultimately produces a complex, fully patterned adult organism. This problem is studied on many different biological levels, from the molecular to the organismal. Developed in association with the Society for Developmental Biology, WIREs Developmental Biology will provide a unique interdisciplinary forum dedicated to fostering excellence in research and education and communicating key advances in this important field. The collaborative and integrative ethos of the WIREs model will facilitate connections to related disciplines such as genetics, systems biology, bioengineering, and psychology. The topical coverage of WIREs Developmental Biology includes: Establishment of Spatial and Temporal Patterns; Gene Expression and Transcriptional Hierarchies; Signaling Pathways; Early Embryonic Development; Invertebrate Organogenesis; Vertebrate Organogenesis; Nervous System Development; Birth Defects; Adult Stem Cells, Tissue Renewal and Regeneration; Cell Types and Issues Specific to Plants; Comparative Development and Evolution; and Technologies.