Anticancer Molecules in Brain: Implication for Novel Strategy for Cancer Immunotherapy.

Clinical and epidemiological studies have demonstrated that macroenvironmental factors are risk factors for the development and progression of tumor [1]. Macroenvironmental factors include a patient's physical, social environment and specific psychosocial factors such as chronic stress, depression, and lack of social support. These observations raise intriguing questions on the brain-cancer connection. What are the molecules in brain linking environmental factors to cancer? Through which pathways do these brain molecules modulate the peripheral cancer? How do these molecules impact tumour growth and progression? The effects and mechanisms of the macroenvironment on systemic cancer are much less well defined, because most basic cancer research focuses on microenvironmental factors of tumor.