含游离c末端肽库的合成与筛选。

Q4 Biochemistry, Genetics and Molecular Biology

Current Topics in Peptide and Protein Research Pub Date : 2014-01-01

Yen-Chih Wang, Mark D Distefano

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引用次数: 0

摘要

肽库是研究蛋白质结构与功能关系的有效工具。具有游离c末端的肽库的创建提出了独特的合成挑战。在这篇综述中，描述了使用固相肽合成或噬菌体展示来创建肽库的方法。本文还报道了这些文库的筛选方法及其在研究几个重要生物学问题中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis and screening of peptide libraries with free C-termini.

本刊更多论文

Synthesis and screening of peptide libraries with free C-termini.

Peptide libraries are useful tools to investigate the relationship between structure and function of proteins. The creation of peptide libraries with free C-termini presents unique synthetic challenges. In this review, methods for creating peptide libraries using either solid-phase peptide synthesis or phage display are described. Methods for screening such libraries and their application in studying several important biological problems are also reported.

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来源期刊

Current Topics in Peptide and Protein Research Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Current Topics in Peptide & Protein Research provides a medium for the publication of review articles and original research papers on various aspects of peptide and protein Research. It covers all aspects of amino acid, peptide, peptidomimetic, and protein science, including chemical, biophysical, biological and pharmaceutical aspects.