新药物的发现和开发。

Q2 Medicine

Progress in molecular and subcellular biology Pub Date : 2017-01-01 DOI:10.1007/978-3-319-51284-6_3

Vesna Erakovic Haber, Radan Spaventi

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引用次数: 7

摘要

目前，药物的发现和开发过程是按照相对规范的阶段顺序进行的，从发现开始，然后是临床前、临床和非临床开发。发现阶段分为热门发现阶段、潜在客户生成阶段、潜在客户优化阶段和候选人识别阶段。整个过程的主要驱动因素是监管要求和旨在通过早期淘汰不太可能的候选药物来消除不必要的支出。海洋产品一旦被纯化、分离并生产出所需的数量，就会遵循与任何其他合成药物相同的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Discovery and Development of Novel Drugs.

Drug discovery and development process is nowadays conducted in relatively standardised sequence of phases, starting with Discovery and being followed by Preclinical, Clinical and Non-Clinical Development. Discovery phase is divided in Hit Finding, Lead generation, Lead Optimisation and Candidate Identification Phase. Main drivers of the whole process are regulatory requirements and the aim to eliminate the unnecessary spending by early elimination of unlikely drug candidates. Marine products, once purified, isolated and produced in required quantities, follow the same route as any other synthetic drug.

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来源期刊

Progress in molecular and subcellular biology Medicine-Medicine (all)

CiteScore

3.30

自引率

0.00%

发文量

期刊介绍： Molecular biology has been providing an overwhelming amount of data on the structural components and molecular machineries of the cell and its organelles and the complexity of intra- and intercellular communication. The molecular basis of hereditary and acquired diseases is beginning to be unravelled, and profound new insights into development and evolutionary biology have been gained from molecular approaches. Progress in Molecular and Subcellular Biology summarises the most recent developments in this fascinating area of biology.