{"title":"癌症生物标志物的临床应用途径。","authors":"N Lynn Henry","doi":"10.1080/00365513.2016.1206441","DOIUrl":null,"url":null,"abstract":"<p><p>Biomarkers play a key role in the diagnosis and management of patients with cancer, and are important for fulfilling the promise of precision medicine in oncology. However, although numerous biomarkers have been shown to have clinical validity, many have not undergone rigorous testing to demonstrate clinical utility so that they can be appropriately incorporated into clinical care. This review article highlights the characteristics of a good biomarker and the steps required to demonstrate clinical utility, and gives examples of both successful established biomarkers and promising new tissue-based and circulating biomarkers on the horizon. </p>","PeriodicalId":76518,"journal":{"name":"Scandinavian journal of clinical and laboratory investigation. Supplementum","volume":"245 ","pages":"S17-21"},"PeriodicalIF":0.0000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/00365513.2016.1206441","citationCount":"4","resultStr":"{\"title\":\"The pathway to clinical use of a cancer biomarker.\",\"authors\":\"N Lynn Henry\",\"doi\":\"10.1080/00365513.2016.1206441\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Biomarkers play a key role in the diagnosis and management of patients with cancer, and are important for fulfilling the promise of precision medicine in oncology. However, although numerous biomarkers have been shown to have clinical validity, many have not undergone rigorous testing to demonstrate clinical utility so that they can be appropriately incorporated into clinical care. This review article highlights the characteristics of a good biomarker and the steps required to demonstrate clinical utility, and gives examples of both successful established biomarkers and promising new tissue-based and circulating biomarkers on the horizon. </p>\",\"PeriodicalId\":76518,\"journal\":{\"name\":\"Scandinavian journal of clinical and laboratory investigation. Supplementum\",\"volume\":\"245 \",\"pages\":\"S17-21\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/00365513.2016.1206441\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Scandinavian journal of clinical and laboratory investigation. Supplementum\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/00365513.2016.1206441\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2016/7/13 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian journal of clinical and laboratory investigation. Supplementum","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/00365513.2016.1206441","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/7/13 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
The pathway to clinical use of a cancer biomarker.
Biomarkers play a key role in the diagnosis and management of patients with cancer, and are important for fulfilling the promise of precision medicine in oncology. However, although numerous biomarkers have been shown to have clinical validity, many have not undergone rigorous testing to demonstrate clinical utility so that they can be appropriately incorporated into clinical care. This review article highlights the characteristics of a good biomarker and the steps required to demonstrate clinical utility, and gives examples of both successful established biomarkers and promising new tissue-based and circulating biomarkers on the horizon.
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