脉冲波在人腹主动脉瘤内传播的FSI模拟:囊腔几何形状和刚度的影响。

IF 2.3 Q3 ENGINEERING, BIOMEDICAL
Biomedical Engineering and Computational Biology Pub Date : 2016-07-18 eCollection Date: 2016-01-01 DOI:10.4137/BECB.S40094
Han Li, Kexin Lin, Danial Shahmirzadi
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引用次数: 10

摘要

本研究旨在量化动脉脉动流固耦合(FSI)模拟中动脉瘤的几何形状和刚度对脉冲波速度(PWV)和传播的影响。为了获得脉冲波在流体和固体介质中的传播,并研究两种波之间的相互作用,生成了壁面位移和流体速度的时空图。结果表明,腹主动脉瘤(AAA)囊的存在和囊模量的变化对脉冲波的传播既有定性影响(如正向波和反射波的变化模式),也有定量影响(如随着囊刚度的增加,囊内PWV减小,囊外PWV增大)。囊状区域在时空图上被特别识别,在波传播中有多个短行正/反射波的中断区域,这是由囊状区域内边界条件的变化引起的。然而,与流体速度相比,囊腔刚度的变化在壁面位移时空图上更为明显。我们得出结论,根据固体和流体脉冲波可以识别囊的存在,并可以估计囊的性质。本研究证明了动脉搏动过程中FSI动力学数值模拟的初步发现,可作为实验和体内研究的参考。未来的研究需要证明该方法在识别非常轻微的囊泡方面的可行性,这些囊泡无法从医学成像中检测到,在早期疾病开始时存在材料性能退化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

FSI Simulations of Pulse Wave Propagation in Human Abdominal Aortic Aneurysm: The Effects of Sac Geometry and Stiffness.

FSI Simulations of Pulse Wave Propagation in Human Abdominal Aortic Aneurysm: The Effects of Sac Geometry and Stiffness.

FSI Simulations of Pulse Wave Propagation in Human Abdominal Aortic Aneurysm: The Effects of Sac Geometry and Stiffness.

FSI Simulations of Pulse Wave Propagation in Human Abdominal Aortic Aneurysm: The Effects of Sac Geometry and Stiffness.

This study aims to quantify the effects of geometry and stiffness of aneurysms on the pulse wave velocity (PWV) and propagation in fluid-solid interaction (FSI) simulations of arterial pulsatile flow. Spatiotemporal maps of both the wall displacement and fluid velocity were generated in order to obtain the pulse wave propagation through fluid and solid media, and to examine the interactions between the two waves. The results indicate that the presence of abdominal aortic aneurysm (AAA) sac and variations in the sac modulus affect the propagation of the pulse waves both qualitatively (eg, patterns of change of forward and reflective waves) and quantitatively (eg, decreasing of PWV within the sac and its increase beyond the sac as the sac stiffness increases). The sac region is particularly identified on the spatiotemporal maps with a region of disruption in the wave propagation with multiple short-traveling forward/reflected waves, which is caused by the change in boundary conditions within the saccular region. The change in sac stiffness, however, is more pronounced on the wall displacement spatiotemporal maps compared to those of fluid velocity. We conclude that the existence of the sac can be identified based on the solid and fluid pulse waves, while the sac properties can also be estimated. This study demonstrates the initial findings in numerical simulations of FSI dynamics during arterial pulsations that can be used as reference for experimental and in vivo studies. Future studies are needed to demonstrate the feasibility of the method in identifying very mild sacs, which cannot be detected from medical imaging, where the material property degradation exists under early disease initiation.

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