一例加湿器消毒液毒理学分析。

Q3 Medicine
Environmental Health and Toxicology Pub Date : 2016-07-03 eCollection Date: 2016-01-01 DOI:10.5620/eht.e2016013
Kawangsik Park
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引用次数: 20

摘要

对暴露于聚六亚甲基胍(PHMG)的患者和死亡人数的分析表明,PHMG主要导致肺纤维化等肺部疾病。但是,目前还没有对其他器官进行研究。因此,需要对毒理学技术进行深入讨论,以确定PHMG是否对肺以外的器官有毒。对于暴露于PHMG的靶器官毒性测试,首先必须进行毒性动力学研究。然而,由于聚合物PHMG的分析不容易,注射到体内的PHMG的测量方法尚未建立,因此必须首先进行包括放射性标记化学在内的PHMG分析技术的相关基础研究。此外,暴露-生物标志物和效应-生物标志物的研究也必须进行,主要与临床应用相关。由于暴露于加湿器消毒剂后已经过了很长时间,因此将生物标志物研究应用于患者似乎存在一些局限性。这就是为什么必须对受害者的因果关系进行更全面的毒理学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An analysis of a humidifier disinfectant case from a toxicological perspective.

An analysis of patients and fatalities due to exposure to polyhexamethylene guanidine (PHMG) shows that PHMG causes mainly lung diseases such as pulmonary fibrosis. However, no research on the other organs has been conducted on this matter yet. So, an in-depth discussion on toxicological techniques is needed to determine whether or not PHMG is toxic to organs other than just the lungs. For the test of target organ toxicity by PHMG exposure, a toxicokinetic study must first be conducted. However, measurement method for PHMG injected into the body has not yet been established because it is not easy to analyze polymer PHMG, so related base studies on analytical technique for PHMG including radio-labeling chemistry must come first. Moreover, research on exposure-biomarker and effect-biomarker must also be conducted, primarily related to clinical application. Several limitations seem to be expected to apply the biomarker study to the patient because much time has passed after exposure to the humidifier disinfectant. It is why a more comprehensive toxicological researches must be introduced to the causality for the victims.

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来源期刊
Environmental Health and Toxicology
Environmental Health and Toxicology Medicine-Public Health, Environmental and Occupational Health
CiteScore
2.50
自引率
0.00%
发文量
0
审稿时长
8 weeks
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