【胶囊型复合益生菌制剂“双歧菌”的实验室及实验研究】。

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology Pub Date : 2016-01-01

V A Neschislyaev, M G Stolbova, P A Mokin, E V Orlova, A E Ershov

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引用次数: 0

摘要

在“Microgen”国有公司彼尔姆分公司“Biomed”开发了硬明胶胶囊复合益生菌的组成和工艺。该制剂含有三种生产菌株:植物乳杆菌8P-A3、嗜酸乳杆菌K3W24和两歧双歧杆菌1。该益生菌的实验室和实验(临床前)研究包括拮抗活性、“急性”和“慢性”毒性、制剂对实验动物组织学和血液学的影响。这些研究结果表明，与单一益生菌制剂相比，该益生菌对病原菌群具有较高的抑制活性，且对实验动物无毒性作用。

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[LABORATORY AND EXPERIMENTAL STUDY OF THE COMPLEX PROBIOTIC PREPARATION "BIFILACT-BILS" IN CAPSULATED FORM].

The composition and technology of complex probiotic in hard gelatin capsules was developed in Perm Branch "Biomed" of "Microgen" State Company. The preparation contains three production strains: Lactobacillus plantarum 8P-A3, L. acidophilus K3W24 and Bifidobacterium bifidum 1. Laboratory and experimental (preclinical) study of the probiotic included investigation of the antagonistic activity, "acute" and "chronic" toxicity, the effect of the preparation on histology and hematology of laboratory animals. The result of these studies suggested of the probiotic had high inhibitory activity against pathogenic microflora when compared with probiotic monopreparations and had no toxic effects on laboratory animals.

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Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology

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