Pragya Shrestha, Dilli R Poudel, Ranjan Pathak, Sushil Ghimire, Rashmi Dhital, Madan R Aryal, Maryam Mahmood, Paras Karmacharya
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引用次数: 6
摘要
背景:他汀类药物在感染免疫应答过程中改变炎症细胞信号。这被认为是一种多效性效应。他汀类药物在诸如菌血症等炎症性疾病中的作用一直存在争议。目的:研究他汀类药物对菌血症患者死亡率的影响。材料和方法:检索各大数据库，查找相关临床试验。结果:纳入6项队列研究，共7553例患者。他汀类药物患者的住院死亡率较低(15.36% vs 22.28%)。结论:他汀类药物可能在类似的炎症和感染条件下发挥潜在作用。
Effect of Statins on the Mortality of Bacteremic Patients: A Systematic Review and Meta-analysis of Clinical Trials.
Background: Statins modify inflammatory cell signaling during the immune response to infection. This has been considered as a pleotropic effect. Effects of statins in inflammatory conditions such as bacteremia have been found to be controversial.
Aims: We examined the effect of statins on the mortality of bacteremia patients.
Materials and methods: Major databases were searched for the pertinent clinical trials.
Results: Six cohort studies comprising 7553 patients were included. Hospital mortality was lower (15.36% vs 22.28%) in patients on statin.
Conclusions: There may be a potential role of statins in similar inflammatory and infective conditions.
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