TREXMO:一个支持使用监管职业暴露模型的翻译工具。

Annals of Occupational Hygiene Pub Date : 2016-10-01 Epub Date: 2016-06-29 DOI:10.1093/annhyg/mew042
Nenad Savic, Dimitri Racordon, Didier Buchs, Bojan Gasic, David Vernez
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引用次数: 26

摘要

职业暴露模型在其复杂性、目的和对使用者的专业知识要求水平上差异很大。同一模型中的不同参数可能导致同一暴露情况下的不同暴露估计。本文提出了一个开发的工具来处理这个问题——trexmo或暴露模型的转换。TREXMO集成了ART v.1.5、STOFFENMANAGER(®)v.5.1、ECETOC TRA v.3、MEASE v.1.02.01、EMKG-EXPO-TOOL、EASE v.2.0等六种常用的职业暴露模型。通过启用这六个模型参数之间的半自动转换,TREXMO方便了它们的同时使用。对于给定的暴露情况(由其中一个模型中的一组参数定义),TREXMO为用户提供最合适的参数,以便在其他暴露模型中使用。结果表明,一旦在ART中设置了暴露情况和参数,TREXMO将其他模型中可能出现的结果数量减少了1-4个数量级。该工具应设法减少六个模型中参数的不确定输入或选择,提高用户之间的可靠性,并减少针对给定暴露情况运行多个模型所需的时间。除了这些优势之外,化学品注册人和当局应该受益于根据化学品法规,评估,授权和限制(REACH)对危险化学品的风险特征进行更可靠的暴露估计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
TREXMO: A Translation Tool to Support the Use of Regulatory Occupational Exposure Models.

Occupational exposure models vary significantly in their complexity, purpose, and the level of expertise required from the user. Different parameters in the same model may lead to different exposure estimates for the same exposure situation. This paper presents a tool developed to deal with this concern-TREXMO or TRanslation of EXposure MOdels. TREXMO integrates six commonly used occupational exposure models, namely, ART v.1.5, STOFFENMANAGER(®) v.5.1, ECETOC TRA v.3, MEASE v.1.02.01, EMKG-EXPO-TOOL, and EASE v.2.0. By enabling a semi-automatic translation between the parameters of these six models, TREXMO facilitates their simultaneous use. For a given exposure situation, defined by a set of parameters in one of the models, TREXMO provides the user with the most appropriate parameters to use in the other exposure models. Results showed that, once an exposure situation and parameters were set in ART, TREXMO reduced the number of possible outcomes in the other models by 1-4 orders of magnitude. The tool should manage to reduce the uncertain entry or selection of parameters in the six models, improve between-user reliability, and reduce the time required for running several models for a given exposure situation. In addition to these advantages, registrants of chemicals and authorities should benefit from more reliable exposure estimates for the risk characterization of dangerous chemicals under Regulation, Evaluation, Authorisation and restriction of CHemicals (REACH).

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