外阴细胞血管纤维瘤:一个鲜为人知的实体,一个病例报告和文献复习。

Q2 Medicine
BMC Clinical Pathology Pub Date : 2016-06-04 eCollection Date: 2016-01-01 DOI:10.1186/s12907-016-0030-z
Mouna Khmou, Najat Lamalmi, Abderrahmane Malihy, Lamia Rouas, Zaitouna Alhamany
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引用次数: 20

摘要

背景:细胞血管纤维瘤是一种新发现的部位特异性肿瘤。组织学上,CAF是一种良性间质肿瘤,其特征有两个主要成分:平淡的梭形细胞和明显的小到中型血管,并伴有壁透明化。病变的惰性性质由其组成基质细胞的均匀性和核非典型性的缺乏所强调。免疫组织化学表征有助于将细胞血管纤维瘤与其他间质病变区分开来。病例介绍:我们报告的情况下,一个37岁的妇女,表现为无痛结节累及外阴。病变逐渐增大;单纯切除,随访无明显变化。大体检查显示一个3× 3× 2,5厘米的边界清晰、坚固的肿瘤。组织学上,肿瘤由均匀的短梭形细胞组成,在水肿到纤维间质中增殖,并有许多小到中等的厚壁血管。免疫组化染色证实了细胞性血管纤维瘤的诊断。结论:在本报告中,我们旨在通过文献回顾来描述这种罕见实体的临床,病理和免疫组织化学特征,并讨论其他外阴间质病变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cellular angiofibroma of the vulva: a poorly known entity, a case report and literature review.

Cellular angiofibroma of the vulva: a poorly known entity, a case report and literature review.

Cellular angiofibroma of the vulva: a poorly known entity, a case report and literature review.

Cellular angiofibroma of the vulva: a poorly known entity, a case report and literature review.

Background: Cellular angiofibroma represents a newly described, site specific tumor. Histologically, CAF is a benign mesenchymal neoplasm characterized by two principal components: bland spindle cells and prominent small to medium-sized vessels with mural hyalinization. The indolent nature of the lesion is underscored by the uniformity of its constituent stromal cells, and their lack of nuclear atypia. Characterization by immunohistochemistry is helpful distinguishing Cellular angiofibroma from other mesenchymal lesions.

Case presentation: We report the case of a 37-year-old woman, presenting with a painless nodule involving the vulva. This lesion had gradually increased in size; a simple excision was performed, and follow up was unremarkable. Gross examination showed a well circumscribed, firm tumor measuring 3× 3 × 2,5 cm. Histologically, the tumor was composed of uniform, short spindle-shaped cells, proliferating in an edematous to fibrous stroma and numerous small to medium-sized thick-walled vessels. A panel of immunohistochemical stains was performed, and confirmed the diagnosis of Cellular angiofibroma.

Conclusion: In this report we aim to describe the clinical, pathological and immunohistochemical features of this rare entity through a literature review, and to discuss other vulvar mesenchymal lesions.

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来源期刊
BMC Clinical Pathology
BMC Clinical Pathology Medicine-Pathology and Forensic Medicine
CiteScore
3.30
自引率
0.00%
发文量
0
期刊介绍: BMC Clinical Pathology is an open access journal publishing original peer-reviewed research articles in all aspects of histopathology, haematology, clinical biochemistry, and medical microbiology (including virology, parasitology, and infection control). BMC Clinical Pathology (ISSN 1472-6890) is indexed/tracked/covered by PubMed, CAS, EMBASE, Scopus and Google Scholar.
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