l1:细胞粘附和更多

Q Medicine

Progress in Histochemistry and Cytochemistry Pub Date : 2016-08-01 DOI:10.1016/j.proghi.2016.05.001

Timur R. Samatov , Daniel Wicklein , Alexander G. Tonevitsky

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引用次数: 63

摘要

L1CAM是免疫球蛋白超家族中的一种细胞粘附分子，最初被发现在神经系统的发育中起着重要作用。L1CAM被证明在不同的癌症中具有预后价值，并且是抗癌治疗的一个有希望的靶点。本文综述了L1CAM的结构和功能、表达调控、在癌症中的作用和治疗潜力等方面的研究进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

L1CAM: Cell adhesion and more

L1CAM is a cell adhesion molecule of the immunoglobulin superfamily which was originally discovered as a major player in the development of the nervous system. L1CAM was demonstrated to have prognostic value in different cancers and to be a promising target for anti-cancer therapy. Here we overview the present data on L1CAM structure and function, regulation of its expression, role in cancer and therapeutic potential.

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来源期刊

Progress in Histochemistry and Cytochemistry 生物-细胞生物学

CiteScore

4.67

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Progress in Histochemistry and Cytochemistry publishes comprehensive and analytical reviews within the entire field of histochemistry and cytochemistry. Methodological contributions as well as papers in the fields of applied histo- and cytochemistry (e.g. cell biology, pathology, clinical disciplines) will be accepted.