M Forat-Yazdi, F Hosseini-Biouki, J Salehi, H Neamatzadeh, R Masoumi Dehshiri, Z Sadri, F Ghanizadeh, R Sheikhpour, H Zare-Zardini
{"title":"rfc1g80a多态性与急性淋巴细胞白血病的关系:10项研究的回顾和荟萃分析","authors":"M Forat-Yazdi, F Hosseini-Biouki, J Salehi, H Neamatzadeh, R Masoumi Dehshiri, Z Sadri, F Ghanizadeh, R Sheikhpour, H Zare-Zardini","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Evidence indicates RFC1 G80A polymorphism as a risk factor for a number of cancers. Increasing studies have been conducted on the association of RFC1 G80A polymorphism with acute lymphoblastic leukemia (ALL) risk. However, the results were controversial. The aim of the present study was to derive a more precise estimation of the relationship.</p><p><strong>Materials and method: </strong>PubMed, Embase, Web of Science, Cochrane database, and Google Scholar were searched to get the genetic association studies between RFC1 G80A polymorphism and ALL. All eligible studies for the period up to February 2016 were identified. Subgroup analyses regarding ethnicity were also implemented. All statistical analyses were done with CMA 2.0.</p><p><strong>Results: </strong>A total of ten studies comprising of 2,168 ALL cases and 2,693 healthy controls were included in this meta-analysis. Overall, no significant association was detected for allelic model (OR = 1.029, 95 % CI 0.754- 1.405, P=0.000), Dominant model (OR = 1.619, 95 % CI 0.847-3.094, P=0.145), recessive model (OR = 1.169, 95 % CI 10.764-1.790, P=0.429), and homozygote model (OR = 1.288, 95 % CI 0.928-1.788, P=0.130). However, there was an obvious association under the heterozygote model (OR = 1.368, 95 % CI 1.056- 1.772, P=0.018). Also, in the stratified analysis by ethnicity, no significant association of this polymorphism with risk of OC was found in the Asian and Caucasian populations. However, there was not significant heterogeneity between heterozygote genetic model (P = 0.15, I(2) = 33%) in Caucasian. Therefore, we utilized the fixed-effect model to merge OR value.</p><p><strong>Conclusion: </strong>Based on the available evidence, no association between RFC1 G80A Polymorphism and ALL risk was observed, even in the subanalysis by ethnicity. The direction of further research should focus not only on the simple relationship of RFC1 G80A Polymorphism and ALL risk, but also on gene-gene and gene-environment interaction.</p>","PeriodicalId":44212,"journal":{"name":"Iranian Journal of Pediatric Hematology and Oncology","volume":"6 1","pages":"52-63"},"PeriodicalIF":0.4000,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867172/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association Between RFC1 G80A Polymorphism and Acute Lymphoblastic Leukemia: a Review and Meta-Analysis of 10 Studies.\",\"authors\":\"M Forat-Yazdi, F Hosseini-Biouki, J Salehi, H Neamatzadeh, R Masoumi Dehshiri, Z Sadri, F Ghanizadeh, R Sheikhpour, H Zare-Zardini\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Evidence indicates RFC1 G80A polymorphism as a risk factor for a number of cancers. Increasing studies have been conducted on the association of RFC1 G80A polymorphism with acute lymphoblastic leukemia (ALL) risk. However, the results were controversial. The aim of the present study was to derive a more precise estimation of the relationship.</p><p><strong>Materials and method: </strong>PubMed, Embase, Web of Science, Cochrane database, and Google Scholar were searched to get the genetic association studies between RFC1 G80A polymorphism and ALL. All eligible studies for the period up to February 2016 were identified. Subgroup analyses regarding ethnicity were also implemented. All statistical analyses were done with CMA 2.0.</p><p><strong>Results: </strong>A total of ten studies comprising of 2,168 ALL cases and 2,693 healthy controls were included in this meta-analysis. Overall, no significant association was detected for allelic model (OR = 1.029, 95 % CI 0.754- 1.405, P=0.000), Dominant model (OR = 1.619, 95 % CI 0.847-3.094, P=0.145), recessive model (OR = 1.169, 95 % CI 10.764-1.790, P=0.429), and homozygote model (OR = 1.288, 95 % CI 0.928-1.788, P=0.130). However, there was an obvious association under the heterozygote model (OR = 1.368, 95 % CI 1.056- 1.772, P=0.018). Also, in the stratified analysis by ethnicity, no significant association of this polymorphism with risk of OC was found in the Asian and Caucasian populations. However, there was not significant heterogeneity between heterozygote genetic model (P = 0.15, I(2) = 33%) in Caucasian. Therefore, we utilized the fixed-effect model to merge OR value.</p><p><strong>Conclusion: </strong>Based on the available evidence, no association between RFC1 G80A Polymorphism and ALL risk was observed, even in the subanalysis by ethnicity. The direction of further research should focus not only on the simple relationship of RFC1 G80A Polymorphism and ALL risk, but also on gene-gene and gene-environment interaction.</p>\",\"PeriodicalId\":44212,\"journal\":{\"name\":\"Iranian Journal of Pediatric Hematology and Oncology\",\"volume\":\"6 1\",\"pages\":\"52-63\"},\"PeriodicalIF\":0.4000,\"publicationDate\":\"2016-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867172/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Pediatric Hematology and Oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2016/3/15 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Pediatric Hematology and Oncology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2016/3/15 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
摘要
背景:有证据表明RFC1 G80A多态性是许多癌症的危险因素。越来越多的研究表明rfc1g80a多态性与急性淋巴细胞白血病(ALL)风险的关系。然而，结果是有争议的。本研究的目的是对这种关系进行更精确的估计。材料和方法:检索PubMed、Embase、Web of Science、Cochrane数据库和Google Scholar，获取RFC1 G80A多态性与ALL的遗传关联研究。确定了截至2016年2月的所有符合条件的研究。还对种族进行了亚组分析。所有统计分析均采用CMA 2.0。结果:本荟萃分析共纳入了10项研究，包括2168例ALL病例和2693例健康对照。总体而言，等位基因模型(OR = 1.029, 95% CI 0.754 ~ 1.405, P=0.000)、显性模型(OR = 1.619, 95% CI 0.847 ~ 3.094, P=0.145)、隐性模型(OR = 1.169, 95% CI 10.764 ~ 1.790, P=0.429)和纯合子模型(OR = 1.288, 95% CI 0.928 ~ 1.788, P=0.130)未检测到显著相关性。而在杂合子模型下存在明显的相关性(OR = 1.368, 95% CI 1.056 ~ 1.772, P=0.018)。此外，在种族分层分析中，在亚洲和高加索人群中没有发现这种多态性与OC风险的显著关联。而白种人的杂合子遗传模型间差异无显著异质性(P = 0.15, I(2) = 33%)。因此，我们利用固定效应模型对OR值进行合并。结论:根据现有证据，rfc1g80a多态性与ALL风险之间没有关联，即使在种族亚分析中也是如此。进一步的研究方向不应局限于RFC1 G80A多态性与ALL风险的简单关系，而应着眼于基因与基因、基因与环境的相互作用。
Association Between RFC1 G80A Polymorphism and Acute Lymphoblastic Leukemia: a Review and Meta-Analysis of 10 Studies.
Background: Evidence indicates RFC1 G80A polymorphism as a risk factor for a number of cancers. Increasing studies have been conducted on the association of RFC1 G80A polymorphism with acute lymphoblastic leukemia (ALL) risk. However, the results were controversial. The aim of the present study was to derive a more precise estimation of the relationship.
Materials and method: PubMed, Embase, Web of Science, Cochrane database, and Google Scholar were searched to get the genetic association studies between RFC1 G80A polymorphism and ALL. All eligible studies for the period up to February 2016 were identified. Subgroup analyses regarding ethnicity were also implemented. All statistical analyses were done with CMA 2.0.
Results: A total of ten studies comprising of 2,168 ALL cases and 2,693 healthy controls were included in this meta-analysis. Overall, no significant association was detected for allelic model (OR = 1.029, 95 % CI 0.754- 1.405, P=0.000), Dominant model (OR = 1.619, 95 % CI 0.847-3.094, P=0.145), recessive model (OR = 1.169, 95 % CI 10.764-1.790, P=0.429), and homozygote model (OR = 1.288, 95 % CI 0.928-1.788, P=0.130). However, there was an obvious association under the heterozygote model (OR = 1.368, 95 % CI 1.056- 1.772, P=0.018). Also, in the stratified analysis by ethnicity, no significant association of this polymorphism with risk of OC was found in the Asian and Caucasian populations. However, there was not significant heterogeneity between heterozygote genetic model (P = 0.15, I(2) = 33%) in Caucasian. Therefore, we utilized the fixed-effect model to merge OR value.
Conclusion: Based on the available evidence, no association between RFC1 G80A Polymorphism and ALL risk was observed, even in the subanalysis by ethnicity. The direction of further research should focus not only on the simple relationship of RFC1 G80A Polymorphism and ALL risk, but also on gene-gene and gene-environment interaction.
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