青少年和年轻人的成人癌症。

Q4 Biochemistry, Genetics and Molecular Biology

Progress in Tumor Research Pub Date : 2016-01-01 Epub Date: 2016-09-05 DOI:10.1159/000447072

Valérie Laurence, Maria Marples, Daniel P Stark

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引用次数: 4

摘要

年轻人患癌症的模式随着年龄的增长而变化，在青春期和第三个十年从儿童型癌症过渡到成年型癌症。年轻人癌症的危险因素、表现和生物学不同于老年人。在青少年和青壮年(AYAs)中特别重要的因素包括成人型癌症的遗传易感性、诊断不确定性、长期发病率和生育考虑。正在引入新的全身疗法，可以延长生命，甚至增加治愈的机会，但对AYAs的影响尚不确定，因为这些患者在临床试验中的代表性往往不足。在这里，我们讨论了3种最常见的影响成人的AYA癌症的管理，当它们出现在AYA人群中时，因此医学肿瘤学家目前遇到的是乳腺癌，结直肠癌和黑色素瘤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Adult Cancers in Adolescents and Young Adults.

The pattern of cancer seen in young people changes with increasing age, transitioning from childhood- to adult-type cancer in adolescence and the third decade. The risk factors, presentation and biology of cancer in young adults differ from those in the older adult population. Factors of particular significance in adolescents and young adults (AYAs) include genetic predisposition to adult-type cancer, diagnostic uncertainty, long-term morbidity and considerations of fertility. New systemic therapies are being introduced that can prolong life and even increase the chance of cure, but the impact on AYAs is uncertain, as these patients are often under-represented in clinical trials. Here, we discuss the management of AYAs with 3 of the most common cancers affecting adults, when they emerge in the AYA populations, and therefore are currently met by medical oncologists - breast cancer, colorectal cancer and melanoma.

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来源期刊

Progress in Tumor Research 医学-肿瘤学

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： The scientific book series ''Progress in Tumor Research'' aims to provide in depth information about important developments in cancer research. The individual volumes are authored and edited by experts to provide detailed coverage of topics selected as either representing controversial issues or belonging to areas where the speed of developments necessitates the kind of assistance offered by integrative, critical reviews.