左旋咪唑对马来布鲁氏微丝虫的瞬时效应。

Q4 Neuroscience

Invertebrate Neuroscience Pub Date : 2015-09-01 Epub Date: 2015-07-18 DOI:10.1007/s10158-015-0181-0

Eman Mostafa, Bob Storey, Adel Mohammed Farghaly, Hany Abd El-Hai Afify, Afaf Abd El-Raouf Taha, Adrian J Wolstenholme

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引用次数: 5

摘要

左旋咪唑是一种驱虫药，其作用是激活线虫神经肌肉连接处的烟碱乙酰胆碱受体，引起麻痹。本实验测定了左旋咪唑对马来布鲁氏微丝的体外运动能力的影响;孵育2小时后，表观IC50为2.68 mM。较低的药物浓度(如1 mM)可立即引起持续长达1小时的完全麻痹，但在孵育2小时后完全逆转。“恢复”的寄生虫仍然对第二种尼古丁激动剂吡喃醚完全敏感。

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Transient effects of levamisole on Brugia malayi microfilariae.

Levamisole is an anthelmintic drug that acts by activating nicotinic acetylcholine receptors at the nematode neuromuscular junction and causing paralysis. We measured the in vitro effects of levamisole on the motility of Brugia malayi microfilariae; after 2 h incubation the apparent IC50 was 2.68 mM. Lower drug concentrations, such as 1 mM, caused an immediate total paralysis that lasted for up to 1 h, but was completely reversed by 2 h of incubation. The 'recovered' parasites were still completely susceptible to application of a second nicotinic agonist, pyrantel.

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来源期刊

Invertebrate Neuroscience NEUROSCIENCES-

自引率

0.00%

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审稿时长

>12 weeks

期刊介绍： Invertebrate Neurosciences publishes peer-reviewed original articles, reviews and technical reports describing recent advances in the field of invertebrate neuroscience. The journal reports on research that exploits the simplicity and experimental tractability of the invertebrate preparations to underpin fundamental advances in neuroscience. Articles published in Invertebrate Neurosciences serve to highlight properties of signalling in the invertebrate nervous system that may be exploited in the field of antiparisitics, molluscicides and insecticides. Aspects of particular interest include: Functional analysis of the invertebrate nervous system; Molecular neuropharmacology and toxicology; Neurogenetics and genomics; Functional anatomy; Neurodevelopment; Neuronal networks; Molecular and cellular mechanisms of behavior and behavioural plasticity.