新型隐球菌毒力相关酶研究。

Eukaryotic Cell Pub Date : 2015-12-01 Epub Date: 2015-10-09 DOI:10.1128/EC.00103-15
Fausto Almeida, Julie M Wolf, Arturo Casadevall
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引用次数: 82

摘要

酶在真菌的发病机制中起着关键作用。操纵酶的表达或活性可以显著改变感染过程,酶的表达谱可以是疾病的标志。因此,酶是有价值的目标,以更好地了解发病机制和确定对抗真菌感染的新选择。基因组学、蛋白质组学、转录组学和质谱学的进步使鉴定和表征新的真菌酶成为可能。本文综述了新型隐球菌毒力相关酶的研究进展。新形态芽孢杆菌的酶组是为了环境生存而进化的,但其中一些酶在哺乳动物宿主的定殖中起双重作用。我们还讨论了基于潜在酶学的新的治疗和诊断策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Virulence-Associated Enzymes of Cryptococcus neoformans.

Virulence-Associated Enzymes of Cryptococcus neoformans.

Enzymes play key roles in fungal pathogenesis. Manipulation of enzyme expression or activity can significantly alter the infection process, and enzyme expression profiles can be a hallmark of disease. Hence, enzymes are worthy targets for better understanding pathogenesis and identifying new options for combatting fungal infections. Advances in genomics, proteomics, transcriptomics, and mass spectrometry have enabled the identification and characterization of new fungal enzymes. This review focuses on recent developments in the virulence-associated enzymes from Cryptococcus neoformans. The enzymatic suite of C. neoformans has evolved for environmental survival, but several of these enzymes play a dual role in colonizing the mammalian host. We also discuss new therapeutic and diagnostic strategies that could be based on the underlying enzymology.

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来源期刊
Eukaryotic Cell
Eukaryotic Cell 生物-微生物学
自引率
0.00%
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0
审稿时长
1 months
期刊介绍: Eukaryotic Cell (EC) focuses on eukaryotic microbiology and presents reports of basic research on simple eukaryotic microorganisms, such as yeasts, fungi, algae, protozoa, and social amoebae. The journal also covers viruses of these organisms and their organelles and their interactions with other living systems, where the focus is on the eukaryotic cell. Topics include: - Basic biology - Molecular and cellular biology - Mechanisms, and control, of developmental pathways - Structure and form inherent in basic biological processes - Cellular architecture - Metabolic physiology - Comparative genomics, biochemistry, and evolution - Population dynamics - Ecology
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