kras驱动的非小细胞肺癌基因工程小鼠模型综述

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Protocols in Pharmacology Pub Date : 2015-09-01 DOI:10.1002/0471141755.ph1435s70

Clare Sheridan, Julian Downward

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引用次数: 10

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Overview of KRAS-Driven Genetically Engineered Mouse Models of Non-Small Cell Lung Cancer

KRAS, the most frequently mutated oncogene in non-small cell lung cancer, has been utilized extensively to model human lung adenocarcinomas. The results from such studies have enhanced considerably an understanding of the relationship between KRAS and the development of lung cancer. Detailed in this overview are the features of various KRAS-driven genetically engineered mouse models (GEMMs) of non-small cell lung cancer, their utilization, and the potential of these models for the study of lung cancer biology. © 2015 by John Wiley & Sons, Inc.

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Current Protocols in Pharmacology Pharmacology, Toxicology and Pharmaceutics-Pharmacology

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