Ernestina Schipani, Laura Mangiavini, Christophe Merceron
{"title":"HIF-1α和生长板发育:我们真正知道的。","authors":"Ernestina Schipani, Laura Mangiavini, Christophe Merceron","doi":"10.1038/bonekey.2015.99","DOIUrl":null,"url":null,"abstract":"<p><p>Adaptation to low oxygen tension or hypoxia is a critical event in development and tissue homeostasis. Studies by us and others have shown that the fetal growth plate is an avascular tissue with a gradient of oxygenation, and the transcription factor hypoxia-inducible factor-1α (HIF-1α) is essential for its development. In this brief review, we will summarize our current understanding of the role of HIF-1α in fetal growth plate development, and we will discuss yet unanswered questions in the field of hypoxia and endochondral bone formation. </p>","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":" ","pages":"730"},"PeriodicalIF":0.0000,"publicationDate":"2015-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2015.99","citationCount":"15","resultStr":"{\"title\":\"HIF-1α and growth plate development: what we really know.\",\"authors\":\"Ernestina Schipani, Laura Mangiavini, Christophe Merceron\",\"doi\":\"10.1038/bonekey.2015.99\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Adaptation to low oxygen tension or hypoxia is a critical event in development and tissue homeostasis. Studies by us and others have shown that the fetal growth plate is an avascular tissue with a gradient of oxygenation, and the transcription factor hypoxia-inducible factor-1α (HIF-1α) is essential for its development. In this brief review, we will summarize our current understanding of the role of HIF-1α in fetal growth plate development, and we will discuss yet unanswered questions in the field of hypoxia and endochondral bone formation. </p>\",\"PeriodicalId\":72441,\"journal\":{\"name\":\"BoneKEy reports\",\"volume\":\" \",\"pages\":\"730\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1038/bonekey.2015.99\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BoneKEy reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/bonekey.2015.99\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2015/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BoneKEy reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/bonekey.2015.99","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2015/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
HIF-1α and growth plate development: what we really know.
Adaptation to low oxygen tension or hypoxia is a critical event in development and tissue homeostasis. Studies by us and others have shown that the fetal growth plate is an avascular tissue with a gradient of oxygenation, and the transcription factor hypoxia-inducible factor-1α (HIF-1α) is essential for its development. In this brief review, we will summarize our current understanding of the role of HIF-1α in fetal growth plate development, and we will discuss yet unanswered questions in the field of hypoxia and endochondral bone formation.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
