由K1血清型肺炎克雷伯菌分离株引起的隐源性肝脓肿。

IF 1 Q4 INFECTIOUS DISEASES
Journal of Global Infectious Diseases Pub Date : 2022-08-26 eCollection Date: 2022-07-01 DOI:10.4103/jgid.jgid_188_21
John J Psonis, Yamil Michelen, Kasturi Banerjee, Bettina C Fries, Sutthichai Sae-Tia
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引用次数: 0

摘要

高致病性肺炎克雷伯菌(hvKp)是亚洲化脓性肝脓肿的常见原因,但在北美相当罕见。在北美描述的病例中,只有偶尔的报告描述了分子菌株分型以确认K1菌株为病原体。我们报告了一名56岁的西班牙裔女性,以前没有腹部病理,最近没有旅行,由于社区获得性K1血清型肺炎克雷伯菌分离株,她表现为亚急性腹痛,并出现菌血症和单微生物化脓性肝脓肿。在这个病例中,感染很早就被发现,因此患者成功地接受了经皮引流和长期抗生素治疗。Hvkp可造成发病率和死亡率高的严重侵袭性疾病,最近这些菌株出现的多药耐药性对公共卫生构成严重威胁。此外,从一名没有流行病学危险因素的西班牙裔患者的隐源性肝脓肿中分离出K1肺炎克雷伯菌菌株,引起了人们对高毒力菌株在亚洲人群之外更广泛传播的关注。因此,在西班牙裔人群中对hvKp感染的高怀疑指数可能是至关重要的,因为高毒力菌株可能导致严重的转移性感染,具有显著的发病率和死亡率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cryptogenic Liver Abscess Caused by a K1 Serotype <i>Klebsiella pneumoniae</i> Isolate.

Cryptogenic Liver Abscess Caused by a K1 Serotype <i>Klebsiella pneumoniae</i> Isolate.

Cryptogenic Liver Abscess Caused by a K1 Serotype Klebsiella pneumoniae Isolate.
Hypervirulent Klebsiella pneumoniae (hvKp) is a common cause of pyogenic liver abscesses in Asia but is quite uncommon in North America. Among the cases described in North America, only occasional reports have described molecular strain typing to confirm the K1 strain as the causative agent. We report a 56-year-old Hispanic female with no previous intra-abdominal pathology and no recent travel, who presented with subacute abdominal pain and developed bacteremia and monomicrobial pyogenic liver abscess due to a community-acquired K1 serotype K. pneumoniae isolate. In this case, the infection was recognized early, so the patient was successfully treated with percutaneous drainage and prolonged antibiotic therapy. Hvkp can cause severe invasive disease with high morbidity and mortality, and the recent emergence of multidrug resistance in these strains poses a serious threat to public health. In addition, the isolation of a K1 K. pneumoniae strain from a cryptogenic liver abscess in a Hispanic patient with no epidemiologic risk factors raises concern for a wider spread of the hypervirulent strain beyond Asian populations. Therefore, a high index of suspicion for hvKp infection in the Hispanic population can be crucial as the hypervirulent strain is likely to cause severe metastatic infection with significant morbidity and mortality.
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来源期刊
CiteScore
3.30
自引率
0.00%
发文量
31
审稿时长
29 weeks
期刊介绍: JGID encourages research, education and dissemination of knowledge in the field of Infectious Diseases across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in Infectious Diseases to promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.
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