宫颈上皮细胞中相对端粒长度与人乳头瘤病毒高载量风险的关系

IF 0.5 4区 医学 Q4 GENETICS & HEREDITY
Balkan Journal of Medical Genetics Pub Date : 2022-06-05 eCollection Date: 2021-11-01 DOI:10.2478/bjmg-2021-0026
A H Albosale, E V Mashkina
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引用次数: 0

摘要

纠缠性高危HPV (HR-HPV)感染是宫颈癌发生过程中最常见的触发因素。在这方面,癌症的存在可以归咎于端粒延长或缩短。本文探讨了两组女性中相对端粒长度和病毒载量之间可能的相关性,即高危HPV感染和未感染HPV的女性。因此,本研究对每组50名妇女组成的样本进行了评估。采用Amplisens HPV HCR筛选滴度- frt PCR风筝进行定量分析。实时荧光定量PCR测定相对端粒长度。在两个HPV载量组中,年龄和端粒长度之间没有相关性。与对照组妇女相比,在HPV高负荷妇女的宫颈细胞样本中发现端粒缩短。端粒缩短与HPV载量升高有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Association of Relative Telomere Length and Risk of High Human Papillomavirus Load in Cervical Epithelial Cells.

Association of Relative Telomere Length and Risk of High Human Papillomavirus Load in Cervical Epithelial Cells.

Association of Relative Telomere Length and Risk of High Human Papillomavirus Load in Cervical Epithelial Cells.

Importunate high-risk HPV (HR-HPV) infection is the most common trigger for the cervical carcinogenesis process. In this respect, the presence of cancer can be imputed to telomere lengthening or shortening. This paper explores the possible correlation between relative telomere length and viral load in two groups of women, namely: those with high-risk HPV infection and those who do not have this infection. Thus, samples comprising of 50 women in each group were evaluated for this research. The Amplisens HPV HCR screen-titre-FRT PCR kite was employed for quantitative analysis. Relative telomere length was quantified by real-time PCR. In each of the two HPV load groups, there was no correlation between age and telomere length. Telomere shortening was found in the cervical cell samples of women with high HPV loads, compared with women in the control group. Telomere shortening is associated with elevated HPV loads.

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来源期刊
CiteScore
1.00
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Balkan Journal of Medical Genetics is a journal in the English language for publication of articles involving all branches of medical genetics: human cytogenetics, molecular genetics, clinical genetics, immunogenetics, oncogenetics, pharmacogenetics, population genetics, genetic screening and diagnosis of monogenic and polygenic diseases, prenatal and preimplantation genetic diagnosis, genetic counselling, advances in treatment and prevention.
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