口腔颌面部肌成纤维细胞病变的组织形态学评价、细胞增殖和内皮免疫染色。

IF 2.2 3区 医学
A-G Hassaf-Arreola, C-H Caro-Sánchez, H Domínguez-Malagón, M-E Irigoyen-Camacho, O-P Almeida, C Sánchez-Romero, A Mosqueda-Taylor
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引用次数: 0

摘要

背景:肌成纤维细胞(MF)是具有成纤维细胞和平滑肌细胞特征的间充质细胞。虽然这些通常是反应性细胞,但它们可以导致肌成纤维细胞肿瘤,这些肿瘤可能具有相同的临床和组织形态学特征,但预后不同。本研究的目的是进行组织形态学评估,并比较和评估两种不同的细胞增殖免疫标志物和两种内皮标志物在一组口腔和颌面肌成纤维细胞病变(MFL)中的作用。材料和方法:横断面和回顾性研究。分析39例MFL的人口学、临床、组织形态学和免疫组织化学特征。用Ki67、MCM2、CD34和CD105抗体进行免疫组化反应。采用Kruskal-Wallis检验和Spearman相关分析。结果:结节性筋膜炎(NF) 4例,肌纤维瘤(My) 18例,纤维增生性纤维瘤(DF) 6例,炎性肌纤维母细胞瘤(IMT) 7例,肌纤维母细胞肉瘤(MFS) 4例。女性20例(51.2%);中位年龄13岁[Q1-Q3: 8-24]岁,以下颌骨为主(48.7%)。MCM2免疫染色在MFL;结论:MCM2免疫染色法能更清晰地评估MFL细胞的生长情况。IMT中MCM2和CD34的相关性以及MFS中MCM2和CD105的相关性表明这些病变具有高活动性。这些结果强调了所研究的免疫组织化学标记物作为更好地表征某些MFL的可能工具的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Histomorphological evaluation, cell proliferation and endothelial immunostaining in oral and maxillofacial myofibroblastic lesions.

Background: Myofibroblasts (MF) are mesenchymal cells with features of both fibroblasts and smooth muscle cells. Although these are usually reactive cells, they can lead to myofibroblastic tumors that may share clinical and histomorphological characteristics but with different prognosis. The aim of this study is to perform a histomorphological evaluation as well as to compare and evaluate two different cell proliferation immunomarkers and two endothelial markers in a group of oral and maxillofacial myofibroblastic lesions (MFL).

Material and methods: Cross-sectional and retrospective study. Demographic, clinical, histomorphological and immunohistochemical characteristics of 39 cases of MFL were analyzed. Immunohistochemical reactions were performed with the Ki67, MCM2, CD34 and CD105 antibodies. Kruskal-Wallis test and Spearman correlation analysis were used.

Results: Four cases of nodular fasciitis (NF), 18 myofibromas (My), 6 desmoplastic fibromas (DF), 7 inflammatory myofibroblastic tumors (IMT) and 4 myofibroblastic sarcomas (MFS) were studied. There were twenty women (51.2%); the median age was 13 [Q1-Q3: 8-24] years and most cases occurred in the mandible (48.7%). A statistically significant difference with MCM2 immunostaining (p=0.0221) was observed between the MFL; furthermore, a correlation between CD34 and CD105 immunostaining in NF (p <0.0001) and IMT (p=0.0408), between MCM2 and CD34 in IMT (p=0.0362) and between MCM2 and CD105 in MFS (p <0001) were found.

Conclusions: MCM2 immunostaining could assess more clearly the cell growth fraction in MFL. The correlation between MCM2 and CD34 in IMT and between MCM2 and CD105 in MFS are indicative of the high activity of these lesions. These results emphasize the importance of the studied immunohistochemistry markers as possible tools for a better characterization of some of the MFL.

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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
52
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
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