细胞命运决定中的自噬:从果蝇那里获得的知识。

IF 2.3 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genome Pub Date : 2022-12-01 Epub Date: 2022-10-14 DOI:10.1139/gen-2022-0069

Camille Lacarrière-Keïta, Sonya Nassari, Steve Jean

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引用次数: 0

摘要

自噬是维持成体组织稳态和功能的重要过程，通过自主和非细胞自主的方式保护细胞。通过降解参与细胞信号通路的有毒成分或蛋白质，自噬保持了各种组织中干细胞、祖细胞和分化细胞之间的平衡。在这篇综述中，我们讨论了最近在果蝇身上进行的研究，这些研究强调了自噬在成年细胞命运决定中的新作用，包括静止、增殖、分化和死亡。

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Autophagy in cell fate decisions: knowledge gained from Drosophila.

Autophagy is an important process that maintains adult tissue homeostasis and functions by protecting cells in autonomous and non-cell-autonomous ways. By degrading toxic components or proteins involved in cell signaling pathways, autophagy preserves the balance among stem cells, progenitors, and differentiated cells in various tissues. In this minireview, we discuss recent studies performed in Drosophila that highlight new roles of autophagy in adult cell fate decisions, including quiescence, proliferation, differentiation, and death.

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来源期刊

Genome 生物-生物工程与应用微生物

CiteScore

5.30

自引率

3.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Genome is a monthly journal, established in 1959, that publishes original research articles, reviews, mini-reviews, current opinions, and commentaries. Areas of interest include general genetics and genomics, cytogenetics, molecular and evolutionary genetics, developmental genetics, population genetics, phylogenomics, molecular identification, as well as emerging areas such as ecological, comparative, and functional genomics.