盐酸乙丁醇在D₂O和CD₃OD溶液中的氢-氘交换反应。

IF 1.5 4区医学 Q4 CHEMISTRY, MEDICINAL

Pharmazie Pub Date : 2022-09-01 DOI:10.1691/ph.2022.2419

H Guesmi, J Ben Kraim, A Alatrache, U Holzgrabe

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引用次数: 1

摘要

乙酰丁醇(ACE)的核磁共振光谱可以观察到H/D交换反应。结果表明，当使用氧化氘或氘化甲醇作为氘源和溶剂时，在乙酰丁醇羰基α-位上有氘的掺入。自发氘化是通过以下途径CH₃→CH₂D→CHD→CD₃，通过酮烯醇互变异构反应进行的。此外，LC-MS / QTOF分析证实了提出的H/D交换。为了缩短在乙酰基上观察到的总氘化时间，采用了碱性催化剂。

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Hydrogen-deuterium (H/D) exchange reaction of acebutolol hydrochloride in D₂O and CD₃OD solution.

H/D exchange reactions can be observed by NMR spectroscopy of acebutolol (ACE). The results obtained showed deuterium incorporation at α-posi t ion of the carbonyl group of acebutolol, when using deuterium oxide or deuterated methanol as deuterium source and solvent. The spontaneous deuteration is proceeded by the following pathway CH₃→CH₂D→CHD→CD₃, through a keto-enol tautomerization reaction. Furthermore, LC-MS / QTOF analyses have confirmed the proposed H/D exchange. In order to reduce the time of total deuteration observed at the acetyl group alkaline catalysts were employed.

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来源期刊

Pharmazie 医学-化学综合

CiteScore

3.10

自引率

0.00%

发文量

审稿时长

1.2 months

期刊介绍： The journal DiePharmazie publishs reviews, experimental studies, letters to the editor, as well as book reviews. The following fields of pharmacy are covered: Pharmaceutical and medicinal chemistry; Pharmaceutical analysis and drug control; Pharmaceutical technolgy; Biopharmacy (biopharmaceutics, pharmacokinetics, biotransformation); Experimental and clinical pharmacology; Pharmaceutical biology (pharmacognosy); Clinical pharmacy; History of pharmacy.