免疫化疗-转移性恶性黑色素瘤的一个错过的机会?报告在细胞毒性免疫启动后检查点抑制剂再挑战在重度预处理患者中的治疗成功。

IF 0.9 Q4 DERMATOLOGY
Case Reports in Dermatology Pub Date : 2022-08-29 eCollection Date: 2022-05-01 DOI:10.1159/000525153
Til R Kiderlen, Nicola Delmastro, Friedemann Jobst, Maike de Wit
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引用次数: 0

摘要

转移性恶性黑色素瘤的治疗方法仍然非常有限。在用尽免疫检查点抑制(ICI)和潜在的靶向治疗后,目前没有有希望的替代方案。我们报告了一位83岁的弥散性转移性黑色素瘤患者,在不同方案(包括两种无反应的ICI方案)反复失败后,化疗后对ICI几乎完全有效。目前的结果表明,细胞毒性免疫启动,促进了对先前无反应的ICI的反应。由于到目前为止,恶性黑色素瘤的这一概念还没有建立起来,与其他多种癌症实体相比,我们的病例报告证实了之前的证据,因此提出了一种新的治疗方案,需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Immunochemotherapy - A Missed Opportunity for Metastasized Malignant Melanoma? Reporting a Therapeutic Success with Checkpoint Inhibitor Rechallenge after Cytotoxic Immuno-Priming in a Heavily Pretreated Patient.

Immunochemotherapy - A Missed Opportunity for Metastasized Malignant Melanoma? Reporting a Therapeutic Success with Checkpoint Inhibitor Rechallenge after Cytotoxic Immuno-Priming in a Heavily Pretreated Patient.

Immunochemotherapy - A Missed Opportunity for Metastasized Malignant Melanoma? Reporting a Therapeutic Success with Checkpoint Inhibitor Rechallenge after Cytotoxic Immuno-Priming in a Heavily Pretreated Patient.

Treatment of metastasized malignant melanoma still has very limited therapeutic options. After exhaustion of immuno-checkpoint inhibition (ICI) and potentially targeted therapy, no promising alternatives are currently available. We report on an 83-year-old patient suffering from disseminated metastatic melanoma who showed an almost complete response to ICI following chemotherapy, after repeated failure of different regimens including two nonresponsive regimens of ICI. The presented outcome suggests a cytotoxic immuno-priming, facilitating a response to prior nonresponsive ICI. As this concept has not been established until now for malignant melanoma, in contrast to multiple other cancer entities, our case report corroborates previous evidence and therefore suggests a new treatment option, which should be researched further.

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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
57
审稿时长
9 weeks
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