大黄素的体外和体内抗肺癌活性:RNA-seq转录组分析

IF 3.5 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Aikebaier Maimaiti, Liu Xingliang, Linsen Shi
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引用次数: 0

摘要

大黄素是一种天然的中草药蒽醌提取物。多项研究表明,这种提取物具有抗肿瘤活性,尤其是对肺癌。然而,大黄素的作用模式仍不明确。在这项研究中,我们评估了大黄素在体外和体内对人类肺腺癌的抗肺癌特性及其潜在的分子机制。结果表明,大黄素能显著抑制肺癌细胞的活力,并诱导其凋亡,其水平与正常上皮细胞的凋亡水平相当。此外,RNA-seq转录组分析发现,在大黄素处理的A549和H1650细胞中,65个常见基因(变化>2倍)有显著表达。体外 qRT-PCR 结果证实,在 A549 和 H1650 腺癌细胞系中,4 个基因(ATP6V0D2、C11orf96、TIPARP 和 CDKN1A)上调,9 个基因(TNFSF10、IFIT1、EGLN3、RCOR2、ARRB1、FLVCR2、BAIAP2-DT、FAM111B 和 TGFB2)下调。体内实验表明,与对照组相比,大黄素能显著减少小鼠的肿瘤体积和肿瘤重量。但大黄素对小鼠体重无明显影响。此外,体内qRT-PCR结果显示,与对照组相比,肿瘤组织中有3个基因(ATP6V0D2、C11orf96和TIPARP)上调,6个基因(TNFSF10、IFIT1、EGLN3、BAIAP2-DT、FAM111B和TGFB2)下调。这些研究结果表明,大黄素有助于治疗肺癌,具有作为抗肺癌药物进行进一步研究的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
WITHDRAWN: In Vitro and In Vivo Anti-lung Cancer Activity of Emodin: An RNAseq Transcriptome Analysis

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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来源期刊
Current medicinal chemistry
Current medicinal chemistry 医学-生化与分子生物学
CiteScore
8.60
自引率
2.40%
发文量
468
审稿时长
3 months
期刊介绍: Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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