当EBV血清学需要一个印迹得出结论时:一个病例报告

IF 0.4 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Annales de biologie clinique Pub Date : 2022-07-01 DOI:10.1684/abc.2022.1736

Claire Périllaud-Dubois, Elise Bouthry, Ilias Kounis, Anne-Marie Roque-Afonso, Christelle Vauloup-Fellous

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引用次数: 0

摘要

一名14岁的患者接受了肝移植。移植后3个月，怀疑EBV相关淋巴瘤。移植前后的EBV血清学差异特别大。移植前18个月，血清学分析提示近期有EBV原发感染，移植前4个月，我们分离出抗ebna IgG，移植后5天，血清学分析提示既往感染。全血EBV PCR结果均为阴性。回顾性地进行抗ebv IgG免疫印迹检测。在肝移植前和移植当天，免疫印迹均未显示抗ebv IgG。移植后第5天，患者血清中均有少量IgG抗p18 (VCA)和ebna -1抗体，无其他血清学标志物。这可能是由于手术期间IgG的被动转移。因此，没有理由在该患者肝移植之前或之后进行EBV免疫接种。

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When EBV serology needs a blot to conclude: a case report

A 14-year-old patient underwent liver transplant. Three months after transplantation, EBV associated lymphoma was suspected. EBV serologies before and after transplantation were particularly discrepant. Eighteen months before transplantation, the serological profile suggested a recent EBV primary-infection, four months before transplantation, we had isolated anti-EBNA IgG and five days after transplantation, the serological profile suggested a past infection. All EBV PCR performed on whole blood were negative. Retrospectively, immunoblots anti-EBV IgG were performed. Blots showed no anti-EBV IgG before and until the day of liver transplantation. Five days after transplantation, slight bands of both IgG anti-p18 (VCA) and anti-EBNA-1 were found, without any other serological marker. These were probably due to passive transfers of IgG during surgery. There was therefore no argument for an immunization against EBV before or after liver transplant for this patient.

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来源期刊

Annales de biologie clinique 医学-医学：研究与实验

CiteScore

0.80

自引率

20.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Multidisciplinary information with direct relevance to everyday practice Annales de Biologie Clinique, the official journal of the French Society of Clinical Biology (SFBC), supports biologists in areas including continuing education, laboratory accreditation and technique validation. With original articles, abstracts and accounts of everyday practice, the journal provides details of advances in knowledge, techniques and equipment, as well as a forum for discussion open to the entire community.