线粒体自噬:动脉粥样硬化进展中的关键作用。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

DNA and cell biology Pub Date : 2022-10-01 Epub Date: 2022-08-26 DOI:10.1089/dna.2022.0249

Yanmei Chen, Wenhua Qin, Lu Li, Peng Wu, Dangheng Wei

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引用次数: 3

摘要

自噬维持心血管系统的细胞内稳态，包括心肌细胞、内皮细胞和动脉平滑肌细胞。线粒体自噬是一种选择性自噬，可以特异性地去除受损和功能失调的线粒体，对心血管稳态尤为重要。线粒体自噬功能失调导致心血管疾病，尤其是动脉粥样硬化(AS)。本文就线粒体自噬的调控机制及其在AS中的潜在作用作一综述。研究结果有助于了解动脉粥样硬化病变的病理过程，为AS的预防和临床治疗提供新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mitophagy: Critical Role in Atherosclerosis Progression.

Autophagy maintains intracellular homeostasis in the cardiovascular system, including in cardiomyocytes, endothelial cells (ECs), and arterial smooth muscle cells. Mitophagy, a selective autophagy that specifically removes damaged and dysfunctional mitochondria, is particularly important for cardiovascular homeostasis. Dysfunctional mitophagy contributes to cardiovascular disease, particularly atherosclerosis (AS). This review focuses on the advances of regulator mechanisms of mitophagy and its potential roles in AS. The findings are beneficial to understanding the pathological processes of atherosclerotic lesions and provide new ideas for the prevention and clinical treatment of AS.

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来源期刊

DNA and cell biology 生物-生化与分子生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.