[创伤性疾病患者的全身免疫细胞连锁反应]。

Likars'ka sprava Pub Date : 2015-01-01
I M Plehutsa, R I Sydorchuk, O M Plehutsa
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引用次数: 0

摘要

研究了创伤对细胞免疫参数变化的影响。本研究包括52例不同形式的创伤性疾病患者,年龄18-69岁(37.91-4.28岁)。对照组由16例患者组成,他们接受了与肌肉骨骼系统病理无关的常规手术。主组患者根据病情严重程度分为3组。利用CD3、CD4、CD8、CD22淋巴细胞受体单克隆抗体,采用间接免疫荧光法确定t淋巴细胞亚群,计算综合指标,分析免疫系统细胞连接参数。严重创伤性疾病患者细胞免疫改变的最高表达(II-III级免疫紊乱)(扩大临床图片)。手术干预后,即使没有创伤性损伤,也会显著影响细胞免疫,但创伤性疾病患者的免疫侵犯明显高于对照组患者以外的免疫调节指数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[THE SYSTEMIC IMMUNITY CELLULAR LINK REACTION IN PATIENTS WITH TRAUMATIC ILLNESS].

The effect of trauma on parameters of cellular immunity changes is studied. The study includes 52 patients with various forms of traumatic illness, aged 18-69 years (37.91-4.28). The control group consisted of 16 patients who underwent routine surgery not related to the pathology of musculoskeletal system. All patients of the main group were divided into 3 groups according to severity of the condition. Analysis of parameters of cellular link of immune system was performed by defining subpopulations of T-lymphocytes in indirect immunofluorescence method using a panel of monoclonal antibodies for CD3, CD4, CD8, CD22 lymphocytes' receptors and calculation of integrated indicators. The highest expression (immune disorders of II-III grades) of changes of cellular immunity observed in patients with severe traumatic: illness (expand clinical picture). Surgical intervention, even without traumatic injury significantly impact cellular immunity, but in patients with traumatic illness immunity violation were significantly higher than in comparison groups patients except immunoregulatory index.

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