{"title":"[慢性肾小球肾炎的遗传方面]。","authors":"V Dudnyk, A Zvenigorodska, G Guminska","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The aim of our work was to determine the the gene polymorphism of IL-1β in children with chronic glomerulonephritis. there has been defined the frequency of combinations of allelic variants of cytokines genes of IL-1β and IL-10 in chronic glomerulonephritis in children and found the connection of allelic polymorphism with the disease course, indices of hemopoiesis and IL-1β in serum. The presence of C/T genotype is associated with increased production of interleukin-1β in serum. Genetic polymorphism of genes of interleukin can be a new marker of progression of chronic kidney disease.</p>","PeriodicalId":18100,"journal":{"name":"Likars'ka sprava","volume":" ","pages":"159-60"},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[GENETIC ASPECTS OF CHRONIC GLOMERULONEPHRITIS].\",\"authors\":\"V Dudnyk, A Zvenigorodska, G Guminska\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The aim of our work was to determine the the gene polymorphism of IL-1β in children with chronic glomerulonephritis. there has been defined the frequency of combinations of allelic variants of cytokines genes of IL-1β and IL-10 in chronic glomerulonephritis in children and found the connection of allelic polymorphism with the disease course, indices of hemopoiesis and IL-1β in serum. The presence of C/T genotype is associated with increased production of interleukin-1β in serum. Genetic polymorphism of genes of interleukin can be a new marker of progression of chronic kidney disease.</p>\",\"PeriodicalId\":18100,\"journal\":{\"name\":\"Likars'ka sprava\",\"volume\":\" \",\"pages\":\"159-60\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Likars'ka sprava\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Likars'ka sprava","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The aim of our work was to determine the the gene polymorphism of IL-1β in children with chronic glomerulonephritis. there has been defined the frequency of combinations of allelic variants of cytokines genes of IL-1β and IL-10 in chronic glomerulonephritis in children and found the connection of allelic polymorphism with the disease course, indices of hemopoiesis and IL-1β in serum. The presence of C/T genotype is associated with increased production of interleukin-1β in serum. Genetic polymorphism of genes of interleukin can be a new marker of progression of chronic kidney disease.
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