角膜交联剂的研究进展。

眼科学报 Pub Date : 2014-06-01

Na Li, Xiujun Peng, Zhengjun Fan

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引用次数: 0

摘要

角膜胶原与uva -核黄素交联是目前从病理角度预防圆锥角膜进展的唯一方法。直接交联剂的局部应用目前在临床环境中引起了广泛的关注。本文综述了间接或直接交联剂(核黄素、葡萄糖、核糖、戊二醛、甲醛、甘油醛、短链脂肪族β-硝基醇、格尼平)在角膜疾病治疗中的应用研究进展，并分析了各种交联剂的交联疗效、毒性及优缺点，为进一步研究提供临床资料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research progress in corneal cross-linking agents.

Corneal collagen cross-linking with UVA-riboflavin is currently the only method for preventing the progression of keratoconus from the pathological perspective. Topical application of a direct cross-linking agent is now attracting widespread attention in clinical settings. This article reviews the research progress in the application of indirect or direct cross-linking agents (e.g., riboflavin, glucose, ribose, glutaraldehyde, formaldehyde, glyceraldehyde, short chain aliphatic β-nitro alcohol, and genipin) in the treatment of corneal diseases and analyzes the cross-linking efficacy, toxicity, and merits and disadvantages of each cross-linking agent, providing clinical information for further studies.

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来源期刊

眼科学报

自引率

0.00%

发文量

1312

期刊介绍： Eye science was founded in 1985. It is a national medical journal supervised by the Ministry of Education of the People's Republic of China, sponsored by Sun Yat-sen University, and hosted by Sun Yat-sen University Zhongshan Eye Center (in October 2020, it was changed from a quarterly to a monthly, with the publication number: ISSN: 1000-4432; CN: 44-1119/R). It is edited by Ge Jian, former dean of Sun Yat-sen University Zhongshan Eye Center, Liu Yizhi, director and dean of Sun Yat-sen University Zhongshan Eye Center, and Lin Haotian, deputy director of Sun Yat-sen University Zhongshan Eye Center, as executive editor. It mainly reports on new developments and trends in the field of ophthalmology at home and abroad, focusing on basic research in ophthalmology, clinical experience, and theoretical knowledge and technical operations related to epidemiology. It has been included in important databases at home and abroad, such as Chemical Abstract (CA), China Journal Full-text Database (CNKI), China Core Journals (Selection) Database (Wanfang), and Chinese Science and Technology Journal Database (VIP).