[大鼠中枢神经系统综合征下新皮质神经元和神经胶质核中的脂质]。

L N Markevich, I K Kolomiytseva
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引用次数: 0

摘要

研究了大鼠头部局部暴露在200 Gy剂量的x射线辐射下,对新皮质神经元和神经胶质核部分中磷酸脂质和中性脂质数量的影响。在运动障碍修复时,照射后2小时,神经元核中磷脂酰肌醇的数量减少,鞘磷脂的数量增加。新皮层神经胶质细胞核内磷脂酰胆碱和磷脂酰肌醇含量下降,鞘磷脂和胆固醇含量升高。神经核鞘磷脂、磷脂酰肌醇、磷脂酰胆碱和胆固醇参与哺乳动物中枢神经系统综合征的动力学。脂质核在哺乳动物中枢神经系统综合征中的放射抵抗反应已经被证实,脂质在辐照后DNA修复中的可能作用已经被提出。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Lipids in nuclei of neocortex neurons and glia under CNS-syndrome in rats].

The effect of a local exposure of rat heads to X-ray radiation at a dose of 200 Gy on the number of phospho- lipids and neutral lipids in the nuclear fraction ofneocortex neurons and glia has been investigated A decrease in the amount ofphosphatidylinositol and an increase in sphingomyelin in neuronal nuclei occurred 2 h after irradiation at the time of repair of locomotive disorders. The amount of phosphatidylcholine and phosphati- dylinositol dropped, and the amount of sphingomyelin and cholesterol increased in the nuclei ofglial cells of the neocortex. Sphingomyelin, phosphatidylinositol, phosphatidylcholine and cholesterol of neuronal nuclei are involved in the dynamics of the CNS syndrome in mammals. Radio resistance of the responses of lipid nuclei in mammals with the CNS syndrome has been shown and a possible role of lipids in the post-irradia- tion DNA repair has been suggested.

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