现在,多中心随机对照试验呼吁——在乳房x光检查结果显示非典型乳房核心活检后,是否需要手术?

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2015-01-01 Epub Date: 2015-04-21 DOI:10.1155/2015/192579
Nikita Makretsov
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引用次数: 1

摘要

乳腺癌乳房x线摄影筛查导致发现癌前病变和侵袭性病变的频率越来越高。然而,目前的流行病学证据表明,筛查可以降低乳腺癌患者的特定死亡率,但不能降低乳腺癌患者的总体死亡率。由于一组DCIS患者的长期乳腺癌特异性死亡率已经在个位数范围内,因此缺乏通过手术和放疗积极根除DCIS(侵袭前乳腺癌)是否有利于生存的证据。此外,目前尚不清楚是否积极的手术根除非典型乳腺病变,不能诊断DCIS对患者有任何好处。在这里,我们提出了一个随机对照试验模型,以产生高水平的证据,并解决这一困境。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Now, later of never: multicenter randomized controlled trial call--is surgery necessary after atypical breast core biopsy results in mammographic screening settings?

Breast cancer mammographic screening leads to detection of premalignant and preinvasive lesions with an increasing frequency. Nevertheless, current epidemiologic evidence indicates that the screening reduces breast cancer specific mortality, but not overall mortality in breast cancer patients. The evidence is lacking whether aggressive eradication of DCIS (preinvasive form of breast carcinoma) by surgery and radiation is of survival benefit, as long-term breast cancer specific mortality in a cohort of patients with DCIS is already in a single digit percent range. Furthermore, it is currently not known whether the aggressive surgical eradication of atypical breast lesions which fall short of diagnosis of DCIS is of any benefit for the patients. Here we propose a model for a randomized controlled trial to generate high level evidence and solve this dilemma.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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