{"title":"[辐射诱导的黑腹果蝇体细胞和生殖组织细胞DNA断裂]。","authors":"E Yushkova, V Zainullin","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The levels of DNA fragmentation (using a neutral version of the \"Comet assay\" method) in the cells of somatic (brain ganglia) and generative (male gonad) tissues of the inbred individuals of the Drosophila wild-type developing in different conditions of a chronic irradiation were estimated. It was found that the radiobiological effect depends on the genotype and cytotype. Irradiation at low doses (0.42 mGy/h) induces the DNA damage in somatic cells of all the studied lines Drosophila in the same way. With the increase in the intensity of chronic irradiation (3.5mGy/h) a significant level of DNA breaks in neuroblasts was observed only for Harwich and Oregon-R stocks, in the cells of male gonad--for all the studied genotypes.</p>","PeriodicalId":79368,"journal":{"name":"Radiatsionnaia biologiia, radioecologiia","volume":"55 1","pages":"97-103"},"PeriodicalIF":0.0000,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Radiation-induced DNA fragmentation in cells of somatic and generative tissues of Drosophila melanogaster].\",\"authors\":\"E Yushkova, V Zainullin\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The levels of DNA fragmentation (using a neutral version of the \\\"Comet assay\\\" method) in the cells of somatic (brain ganglia) and generative (male gonad) tissues of the inbred individuals of the Drosophila wild-type developing in different conditions of a chronic irradiation were estimated. It was found that the radiobiological effect depends on the genotype and cytotype. Irradiation at low doses (0.42 mGy/h) induces the DNA damage in somatic cells of all the studied lines Drosophila in the same way. With the increase in the intensity of chronic irradiation (3.5mGy/h) a significant level of DNA breaks in neuroblasts was observed only for Harwich and Oregon-R stocks, in the cells of male gonad--for all the studied genotypes.</p>\",\"PeriodicalId\":79368,\"journal\":{\"name\":\"Radiatsionnaia biologiia, radioecologiia\",\"volume\":\"55 1\",\"pages\":\"97-103\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2015-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Radiatsionnaia biologiia, radioecologiia\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiatsionnaia biologiia, radioecologiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
[Radiation-induced DNA fragmentation in cells of somatic and generative tissues of Drosophila melanogaster].
The levels of DNA fragmentation (using a neutral version of the "Comet assay" method) in the cells of somatic (brain ganglia) and generative (male gonad) tissues of the inbred individuals of the Drosophila wild-type developing in different conditions of a chronic irradiation were estimated. It was found that the radiobiological effect depends on the genotype and cytotype. Irradiation at low doses (0.42 mGy/h) induces the DNA damage in somatic cells of all the studied lines Drosophila in the same way. With the increase in the intensity of chronic irradiation (3.5mGy/h) a significant level of DNA breaks in neuroblasts was observed only for Harwich and Oregon-R stocks, in the cells of male gonad--for all the studied genotypes.
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