[尿酰基乙酸含硫酰基肼的合成、异构和降压活性]。

Bioorganicheskaia khimiia Pub Date : 2014-05-01

S A Meshcheriakova, V A Kataev, K V Nikolaeva, V N Perfilova, D D Borodin, I N Tiurenkov

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引用次数: 0

摘要

通过肼- 2-[6-甲基-1-(噻吩-3-基)尿嘧啶-3-基]乙酸与芳醛和苯乙酮衍生物的反应，得到了酰基腙，在DMSO溶液中以E(C=N)-异构体的两种立体异构体的混合物存在，由于肼键周围的内旋受阻。结果表明，所合成的化合物具有抗高血压活性。

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[Synthesis, isomery, and hypotensive activity of thiethane-containing ylidenehydrazides of uracilylacetic acid].

Using reaction of hydrazide 2-[6-methyl-1-(thiethane3-yl)uracil-3-yl]acetic acid with arylaldehydes and acetophenone derivatives were obtained acylhydrazones, which exist in DMSO solution as a mixture of two stereoisomers of a E(C=N)-isomer for due to hindered internal rotation around the hydrazide bond. It was revealed that the synthesized compounds exhibit antihypertensive activity.

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Bioorganicheskaia khimiia

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