Rho GTPase功能的时空控制。

Cellular logistics Pub Date : 2014-05-01 eCollection Date: 2014-04-01 DOI:10.4161/21592780.2014.943618
Konstadinos Moissoglu, Martin Alexander Schwartz
{"title":"Rho GTPase功能的时空控制。","authors":"Konstadinos Moissoglu,&nbsp;Martin Alexander Schwartz","doi":"10.4161/21592780.2014.943618","DOIUrl":null,"url":null,"abstract":"<p><p>Rho family GTPases control almost every aspect of cell physiology and, since their discovery, a wealth of knowledge has accumulated about their biochemical regulation and function. However, each Rho GTPase distributes between multiple cellular compartments, even within the same cell, where they are controlled by multiple regulators and signal to multiple effectors. Thus, major questions about spatial and temporal aspects of regulation remain unanswered. In particular, what are the nano-scale dynamics for their activation, membrane targeting, diffusion, effector activation and GTPase inactivation? How do these mechanisms differ in the different cellular compartments where Rho GTPases function? Addressing these complex aspects of Rho GTPase biology will significantly advance our understanding of the spatial and temporal control of cellular functions.</p>","PeriodicalId":72547,"journal":{"name":"Cellular logistics","volume":"4 2","pages":"e943618"},"PeriodicalIF":0.0000,"publicationDate":"2014-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4161/21592780.2014.943618","citationCount":"18","resultStr":"{\"title\":\"Spatial and temporal control of Rho GTPase functions.\",\"authors\":\"Konstadinos Moissoglu,&nbsp;Martin Alexander Schwartz\",\"doi\":\"10.4161/21592780.2014.943618\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Rho family GTPases control almost every aspect of cell physiology and, since their discovery, a wealth of knowledge has accumulated about their biochemical regulation and function. However, each Rho GTPase distributes between multiple cellular compartments, even within the same cell, where they are controlled by multiple regulators and signal to multiple effectors. Thus, major questions about spatial and temporal aspects of regulation remain unanswered. In particular, what are the nano-scale dynamics for their activation, membrane targeting, diffusion, effector activation and GTPase inactivation? How do these mechanisms differ in the different cellular compartments where Rho GTPases function? Addressing these complex aspects of Rho GTPase biology will significantly advance our understanding of the spatial and temporal control of cellular functions.</p>\",\"PeriodicalId\":72547,\"journal\":{\"name\":\"Cellular logistics\",\"volume\":\"4 2\",\"pages\":\"e943618\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.4161/21592780.2014.943618\",\"citationCount\":\"18\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cellular logistics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4161/21592780.2014.943618\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2014/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellular logistics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4161/21592780.2014.943618","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2014/4/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 18

摘要

Rho家族GTPases几乎控制着细胞生理学的各个方面,自发现以来,人们对其生化调节和功能积累了丰富的知识。然而,每个Rho GTPase分布在多个细胞室之间,甚至在同一个细胞内,它们受到多个调节器的控制,并向多个效应器发出信号。因此,关于调控的空间和时间方面的主要问题仍然没有答案。特别是,它们的活化、膜靶向、扩散、效应物活化和GTPase失活的纳米尺度动力学是什么?这些机制在GTPases发挥作用的不同细胞区室中有何不同?解决Rho GTPase生物学的这些复杂方面将大大促进我们对细胞功能的时空控制的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Spatial and temporal control of Rho GTPase functions.

Spatial and temporal control of Rho GTPase functions.

Rho family GTPases control almost every aspect of cell physiology and, since their discovery, a wealth of knowledge has accumulated about their biochemical regulation and function. However, each Rho GTPase distributes between multiple cellular compartments, even within the same cell, where they are controlled by multiple regulators and signal to multiple effectors. Thus, major questions about spatial and temporal aspects of regulation remain unanswered. In particular, what are the nano-scale dynamics for their activation, membrane targeting, diffusion, effector activation and GTPase inactivation? How do these mechanisms differ in the different cellular compartments where Rho GTPases function? Addressing these complex aspects of Rho GTPase biology will significantly advance our understanding of the spatial and temporal control of cellular functions.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信