mirna对乳腺癌和神经母细胞瘤化疗耐药影响的内省研究进展。

Q3 Biochemistry, Genetics and Molecular Biology

Genetics Research International Pub Date : 2014-01-01 Epub Date: 2014-12-04 DOI:10.1155/2014/743050

Alessia Carta, Rachel Chetcuti, Duncan Ayers

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引用次数: 12

摘要

对常规细胞毒性药物的化疗耐药性可能发生在任何类型的癌症中，这可能是固有的，也可能是随着时间的推移而发展的。研究已经将这种获得性耐药性与通常沉默基因的microRNAs (miRNAs)的异常表达联系起来。在异常水平下，mirna要么获得沉默肿瘤抑制基因的能力，要么失去沉默癌基因的能力。mirna还可以影响药物代谢的途径，如药物外排泵，导致耐药表型。这篇综述的范围是对乳腺癌和神经母细胞瘤研究的特定利基进行内省分析。

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An Introspective Update on the Influence of miRNAs in Breast Carcinoma and Neuroblastoma Chemoresistance.

Chemoresistance to conventional cytotoxic drugs may occur in any type of cancer and this can either be inherent or develop through time. Studies have linked this acquired resistance to the abnormal expression of microRNAs (miRNAs) that normally silence genes. At abnormal levels, miRNAs can either gain ability to silence tumour suppressor genes or else lose ability to silence oncogenes. miRNAs can also affect pathways that are involved in drug metabolism, such as drug efflux pumps, resulting in a resistant phenotype. The scope of this review is to provide an introspective analysis on the specific niches of breast carcinoma and neuroblastoma research.

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来源期刊

Genetics Research International Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

2.90

自引率

0.00%

发文量

期刊介绍： Genetics Research International is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles in all areas of genetics and genomics. The journal focuses on articles bearing on heredity, biochemistry, and molecular biology, as well as clinical findings.