Marília I. Figueira , Henrique J. Cardoso , Sara Correia, Cláudio J. Maia, Sílvia Socorro
{"title":"c-KIT受体及其配体的激素调节:对人类不孕症的影响?","authors":"Marília I. Figueira , Henrique J. Cardoso , Sara Correia, Cláudio J. Maia, Sílvia Socorro","doi":"10.1016/j.proghi.2014.09.001","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>The c-KIT, a tyrosine kinase receptor, and its ligand the </span>stem cell factor (SCF) play an important role in the production of male and female </span>gametes<span><span>. The interaction of SCF with c-KIT is required for germ cell survival and growth, and abnormalities in the activity of the SCF/c-KIT system have been associated with human infertility. Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Therefore, the hormonal (de)regulation of SCF/c-KIT system in the testis and ovary may be a cause underpinning infertility. In the present review, we will discuss the effects of hormones modulating the expression levels of SCF and c-KIT in the human gonads. In addition, the implications of </span>hormonal regulation of SCF/c-KIT system for germ cell development and fertility will be highlighted.</span></p></div>","PeriodicalId":54550,"journal":{"name":"Progress in Histochemistry and Cytochemistry","volume":"49 1","pages":"Pages 1-19"},"PeriodicalIF":0.0000,"publicationDate":"2014-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.proghi.2014.09.001","citationCount":"19","resultStr":"{\"title\":\"Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?\",\"authors\":\"Marília I. Figueira , Henrique J. Cardoso , Sara Correia, Cláudio J. Maia, Sílvia Socorro\",\"doi\":\"10.1016/j.proghi.2014.09.001\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span><span>The c-KIT, a tyrosine kinase receptor, and its ligand the </span>stem cell factor (SCF) play an important role in the production of male and female </span>gametes<span><span>. The interaction of SCF with c-KIT is required for germ cell survival and growth, and abnormalities in the activity of the SCF/c-KIT system have been associated with human infertility. Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Therefore, the hormonal (de)regulation of SCF/c-KIT system in the testis and ovary may be a cause underpinning infertility. In the present review, we will discuss the effects of hormones modulating the expression levels of SCF and c-KIT in the human gonads. In addition, the implications of </span>hormonal regulation of SCF/c-KIT system for germ cell development and fertility will be highlighted.</span></p></div>\",\"PeriodicalId\":54550,\"journal\":{\"name\":\"Progress in Histochemistry and Cytochemistry\",\"volume\":\"49 1\",\"pages\":\"Pages 1-19\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.proghi.2014.09.001\",\"citationCount\":\"19\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Progress in Histochemistry and Cytochemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0079633614000114\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Progress in Histochemistry and Cytochemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0079633614000114","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q","JCRName":"Medicine","Score":null,"Total":0}
Hormonal regulation of c-KIT receptor and its ligand: implications for human infertility?
The c-KIT, a tyrosine kinase receptor, and its ligand the stem cell factor (SCF) play an important role in the production of male and female gametes. The interaction of SCF with c-KIT is required for germ cell survival and growth, and abnormalities in the activity of the SCF/c-KIT system have been associated with human infertility. Recently, it was demonstrated that gonadotropic and sex steroid hormones, among others, regulate the expression of SCF and c-KIT in testicular and ovarian cells. Therefore, the hormonal (de)regulation of SCF/c-KIT system in the testis and ovary may be a cause underpinning infertility. In the present review, we will discuss the effects of hormones modulating the expression levels of SCF and c-KIT in the human gonads. In addition, the implications of hormonal regulation of SCF/c-KIT system for germ cell development and fertility will be highlighted.
期刊介绍：
Progress in Histochemistry and Cytochemistry publishes comprehensive and analytical reviews within the entire field of histochemistry and cytochemistry. Methodological contributions as well as papers in the fields of applied histo- and cytochemistry (e.g. cell biology, pathology, clinical disciplines) will be accepted.
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