口腔癌的近切缘:pT1N0和pT2N0口腔癌复发和生存的近切缘状态的含义

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2014-01-01 Epub Date: 2014-11-11 DOI:10.1155/2014/545372
Sandhya Gokavarapu, Ravi Chander, Nagendra Parvataneni, Sreenivasa Puthamakula
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引用次数: 12

摘要

前言:在所有预后因素中,“切缘状态”是临床医生唯一能控制的因素。目前的指南将>5毫米的组织病理学切缘描述为“清晰切缘”,1-5毫米描述为“近切缘”。已发表资料中对正边距的模糊描述导致许多出版物将微观上的“涉及边距”和“接近边距”与“清晰边距”进行比较。作者试图比较I期和II期口腔鳞状细胞癌边缘闭合和清晰的结果,以探讨边缘状态描述的有效性。患者和方法:对2010年1月至2011年12月在三级肿瘤医院接受治疗的患者进行历史队列调查,并筛选I期和II期原发性口腔鳞状细胞癌。排除切缘或切缘1mm范围内肿瘤的患者,采用局部复发的多因素logistic回归模型和总生存期的Cox回归分析。结果:104例患者符合上述标准,其中“明确切缘”36例,“接近切缘”68例,中位随访39个月。“近切缘”和“清切缘”患者的局部复发(P值:0.0.810)和生存期(P值:0.0.851)无显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Close margins in oral cancers: implication of close margin status in recurrence and survival of pT1N0 and pT2N0 oral cancers.

Introduction: Among all prognostic factors, "margin status" is the only factor under clinician's control. Current guidelines describe histopathologic margin of >5 mm as "clear margin" and 1-5 mm as "close margin." Ambiguous description of positive margin in the published data resulted in comparison of microscopically "involved margin" and "close margin" together with "clear margin" in many publications. Authors attempted to compare the outcome of close and clear margins of stage I and stage II squamous cell carcinoma of oral cavity to investigate the efficacy of description of margin status.

Patients and methods: Historical cohorts of patients treated between January 2010 and December 2011 at tertiary cancer hospital were investigated and filtered for stage I and stage II primary squamous cell carcinomas of oral cavity. Patients with margin status of tumor at margin or within 1mm from cut margin were excluded and analyzed in multivariate logistic regression model for locoregional recurrences and Cox regression for overall survival.

Results: A total of 104 patients fulfilled the abovementioned criteria, of whom 36 were "clear margin" and 68 were "close margin" with median period of follow-up of 39 months. There was no significant difference in locoregional recurrence (P value: 0.0.810) and survival (P value: 0.0.851) among "close margin" and "clear margin" patients.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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